{"id":2,"date":"2012-07-19T05:33:26","date_gmt":"2012-07-18T20:33:26","guid":{"rendered":"http:\/\/misterx95.myds.me\/wordpress\/?page_id=2"},"modified":"2023-09-18T10:42:36","modified_gmt":"2023-09-18T01:42:36","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/misterx95.myds.me\/wordpress\/?page_id=2","title":{"rendered":"Research"},"content":{"rendered":"\n<h3 class=\"has-ast-global-color-0-color has-text-color\">\uac10\uac01, \uc774\uc628 \ucc44\ub110, \uadf8\ub9ac\uace0 \uac00\ub824\uc6c0\uc99d<\/h3>\n\n\n\n<p style=\"font-size:16px\">\uc6b0\ub9ac \uc2e4\ud5d8\uc2e4\uc740 \uac00\ub824\uc6c0\uc99d\uc758 \ub2e4\uc591\ud55c \uce21\uba74 \uc911 \uc8fc\ub85c \uc2e0\uacbd\uacc4, \uadf8 \uc911\uc5d0\uc11c\ub3c4 <strong>\ub9d0\ucd08\uc2e0\uacbd\uacc4 (peripheral nervous system)<\/strong>\uc5d0\uc11c \ubc8c\uc5b4\uc9c0\ub294 \ub2e4\uc591\ud55c \ubd84\uc790 \uae30\uc804\uc744 \uaddc\uba85\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \uc5f0\uad6c\ub97c \uc218\ud589\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uac10\uac01\uc740 \ub9d0\ucd08\uc2e0\uacbd\ub9d0\ub2e8\uc5d0\uc11c \uc804\uae30\uc801\uc778 \uc2e0\ud638\ub85c \ubcc0\ud654\ud558\uc5ec \ucc99\uc218(spinal cord)\ub97c \uc9c0\ub098 \ub1cc\uc758 \ud2b9\uc815 \uc601\uc5ed\uc5d0 \ub3c4\ub2ec\ud558\uac8c \ub418\uba70, \ucd5c\uc885\uc801\uc73c\ub85c \uc774\ub97c \uc778\uc9c0\ud558\uac8c \ub429\ub2c8\ub2e4. \uc9c0\uae08 \uc774 \uc21c\uac04\uc5d0\ub3c4 \ub2e4\uc591\ud55c \uae30\uacc4\uc801, \ubb3c\ub9ac\uc801, \ud654\ud559\uc801\uc778 \uc790\uadf9\ub4e4\uc740 \ub9d0\ucd08\uac10\uac01\uc2e0\uacbd\uc5d0\uc11c \uc989\uac01\uc801\uc73c\ub85c \uc804\uae30\uc801\uc778 \uc2e0\ud638\ub85c \ubc88\uc5ed\ub418\uc5b4 \uc911\ucd94\uc2e0\uacbd\uacc4\ub85c \uc774\ub97c \uc804\uc1a1\ub418\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n<p style=\"font-size:16px\">\uc774\ucc98\ub7fc \uc678\ubd80 \uc790\uadf9\uc758 \uc804\uae30 \uc2e0\ud638\ub85c\uc758 \ubc88\uc5ed \uacfc\uc815\uc5d0\ub294 <span style=\"text-decoration: underline; color: #ff0000;\"><strong>\uc774\uc628 \ucc44\ub110 (ion channel)<\/strong><\/span>\uc774 \uc911\ucd94\uc801\uc778 \uc5ed\ud560\uc744 \ub2f4\ub2f9\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\uc628 \ucc44\ub110\uc774\ub780 \uc138\ud3ec\ub9c9\uc5d0 \uc874\uc7ac\ud558\ub294 \ub9c9\ub2e8\ubc30\uc9c8\uc758 \ud55c \uc885\ub958\uc778\ub370, Na+, K+. Ca2+. Cl-\uacfc \uac19\uc740 \uc774\uc628\ub4e4\uc744 \uc138\ud3ec \uc548\ud30e\uc73c\ub85c \ud1b5\uacfc\ud558\uac8c \ud574\uc8fc\ub294 \ud1b5\ub85c \uc5ed\ud560\uc744 \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc774\uc628 \ucc44\ub110\ub4e4\uc740 \uc790\uadf9\uc774 \uc5c6\uc744 \ub54c\uc5d0\ub294 \ub2eb\ud600 \uc788\ub2e4\uac00 (inactive), \ud2b9\uc815 \uc774\uc628 \ucc44\ub110\uc5d0 \uaf2d \ub9de\ub294 \uc790\uadf9\uc774 \uc8fc\uc5b4\uc9c0\uba74 \ube44\ub85c\uc18c \uc5f4\ub9ac\uac8c \ub418\uba70 (active), \uc774 \ub54c \ud1b5\ub85c\uac00 \uc5f4\ub9ac\uba74\uc11c \uc774\uc628\uc758 \ud750\ub984\uc774 \ubc1c\uc0dd, \ucd5c\uc885\uc801\uc73c\ub85c \uc804\uae30\uc801\uc778 \uc2e0\ud638\ub97c \ub9cc\ub4e4\uac8c \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<p style=\"font-size:16px\">\uc608\ub97c \ub4e4\uc5b4\uc11c \uc0dd\uac01\ud574 \ubcfc\uae4c\uc694? \uac00\ub839, \uace0\ucda7\uac00\ub8e8\ub97c \uba39\uac70\ub098 \ub728\uac70\uc6b4 \ubb3c\uc744 \ub9cc\uc9c0\uba74 \ub9f5\ub2e4 \ubc0f \ub728\uac81\ub2e4\ub77c\ub294 <strong>\uac10\uac01(sensation)<\/strong>\uc774 \uc720\ubc1c\ub41c\ub2e4\ub294 \uac83\uc744 \uc6b0\ub9ac\ub294 \uc798 \uc54c\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0\ub370 \uc774\ub7ec\ud55c \uac10\uac01\uc740 \uacfc\uc5f0 \uc5b4\ub5bb\uac8c \uc778\uc9c0\ub418\ub294 \uac83\uc77c\uae4c\uc694? \ud2b9\ud788 \uc55e\uc11c \uc124\uba85\uc5d0 \ub530\ub974\uba74 \uc774\uc628 \ucc44\ub110\uc774 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ub2f4\ub2f9\ud558\uace0 \uc788\ub2e4\ub294 \ub370 \uacfc\uc5f0 \uadf8\ub7f4\uae4c\uc694?&nbsp;<\/p>\n\n\n\n<p style=\"font-size:16px\">2022\ub144 \ub178\ubca8\uc0dd\ub9ac\ud559\uc0c1\uc744 \uc218\uc0c1\ud55c David Julius\uc758 \uc5f0\uad6c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74, \uc704\uc5d0\uc11c \uc608\uc2dc\ud55c \ub728\uac81\uac70\ub098 \ub9e4\uc6b4 \uc790\uadf9\uc744 \uc804\uae30\uc2e0\ud638\ub85c \ubc14\uafd4\uc8fc\ub294 \uc774\uc628 \ucc44\ub110\uc740 <span style=\"color: #ff0000;\"><strong>TRPV1<\/strong><\/span>\uc774\ub77c \ubd88\ub9ac\ub294 \uc774\uc628 \ucc44\ub110\ub54c\ubb38\uc778 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. TRPV1 \uc774\uc628 \ucc44\ub110\uc744 \uc138\ud3ec\uc5d0 \ubc1c\ud604 \uc2dc\ud0a8 \ub2e4\uc74c \uace0\ucd94\uc758 \ub9e4\uc6b4 \uc131\ubd84\uc778 \ucea1\uc0ac\uc774\uc2e0 (capsaicin)\uc744 \ucc98\ub9ac\ud558\uba74 \uc138\ud3ec \uc548\uc73c\ub85c \uae09\uaca9\ud788 \uc591\uc774\uc628\ub4e4\uc774 \ub4e4\uc5b4\uac00\ub294 \uac83\uc774 \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub610\ud55c, 43\u00b0C \uc774\uc0c1\uc758 \uc5f4\uc790\uadf9\uc744 \uc8fc\uc5b4\ub3c4 \ub9c8\ucc2c\uac00\uc9c0\ub85c TRPV1\uc774 \ud65c\uc131\ud654\ub418\uc5b4 \uc138\ud3ec \uc548\uc73c\ub85c \uc774\uc628\uc758 \ud750\ub984\uc774 \ud615\uc131\ub429\ub2c8\ub2e4. \ub9e4\uc6b4 \uac83\uc744 \uba39\uace0 \ub098\uba74 \uc27d\uac8c \ub354\uc6cc \uc9c0\ub294 \uc774\uc720\ub294 \ubc14\ub85c \uc774 \ub450 \uc790\uadf9\uc774 \ub3d9\uc77c\ud55c \uc774\uc628 \ucc44\ub110\uc778 TRPV1\uc744 \uc790\uadf9\ud588\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4. \uc601\uc5b4\ub85c \ub365\ub2e4\uc640 \ub9f5\ub2e4\ub97c \ub73b\ud558\ub294 hot\uc774\ub77c\ub294 \ub2e8\uc5b4\ub294 \uacb0\uad6d TRPV1 \uc774\uc628 \ucc44\ub110\uc758 \ud65c\uc131\ud654\ub97c \ub73b\ud558\ub294 \ub2e8\uc5b4\uc600\ub358 \uc148\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n<p style=\"font-size:16px\">\uc6b0\ub9ac \uc2e4\ud5d8\uc2e4\uc5d0\uc11c\ub294 \uc911\uc694\ud55c \uac10\uac01 \uc911 \ud558\ub098\uc778 <span style=\"color: #008000;\"><strong>\uac00\ub824\uc6c0\uc99d (itch, pruritus)<\/strong><\/span>\uacfc \uc774\uc628 \ucc44\ub110 \ubc0f G protein-coupled receptor (GPCR)\uacfc\uc758 \uc0c1\uad00\uad00\uacc4\uc5d0 \ub300\ud558\uc5ec \ub2e4\uc591\ud55c \uc5f0\uad6c\ub97c \uc9c4\ud589\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac00\ub824\uc6c0\uc99d\uc758 \ub300\ud45c\uc801\uc778 \uc9c8\ubcd1\uc73c\ub85c \uc544\ud1a0\ud53c\uc131 \ud53c\ubd80\uc5fc\uc744 \ub4e4 \uc218 \uc788\ub294\ub370, \ud658\uc790\uc758 \uc218\ub294 \ud574\ub9c8\ub2e4 \uc99d\uac00\ud558\uace0 \uc788\uc9c0\ub9cc, \ub9ce\uc740 \ud658\uc790\ub4e4\uc774 \ucc38\uc744 \uc218 \uc5c6\ub294 \uac00\ub824\uc6c0\uc99d\uc73c\ub85c \ud798\ub4e4\uc5b4 \ud558\ub294 \ub300\ud45c\uc801\uc778 \ub09c\uce58\uc131 \uc9c8\ud658\uc785\ub2c8\ub2e4. \ud639\uc790\ub294 \u201c\uc544\ud508 \uac83\uc740 \ucc38\uc544\ub3c4 \uac00\ub824\uc6b4 \uac83\uc740 \ubabb \ucc38\uaca0\ub2e4\u201d\ub294 \ub9d0\uc744 \uacf5\uacf5\uc5f0\ud558\uac8c \ud560 \uc815\ub3c4\ub85c \uadf9\uc2ec\ud55c \uac00\ub824\uc6c0\uc99d\uc740 \ud1b5\uc99d \uc774\uc0c1\uc758 \uace0\ud1b5\uc744 \ub3d9\ubc18\ud569\ub2c8\ub2e4. \uac00\ub824\uc6c0\uc99d\uc740 \ud56d\uc0c1 \uae01\ub294 \ud589\uc704\ub97c \ub3d9\ubc18\ud558\uac8c \ub418\ub294\ub370, \uadf9\uc2ec\ud55c \uac00\ub824\uc6c0\uc758 \uacbd\uc6b0 \uae01\ub294 \ud589\uc704\uac00 \ub2e8\uc9c0 \uac00\ub824\uc6c0\uc744 \uc77c\uc2dc\uc801\uc73c\ub85c \uc5c6\uc560\ub294 \uc791\uc6a9\uc5d0 \uba48\ucd94\uc9c0 \uc54a\uace0, \uc8fc\ubcc0 \ubd80\uc704\uc758 \uc0c1\ucc98\ub97c \ub3d9\ubc18\ud558\ub294 \ub4f1 \uc774\ucc28\uc801\uc778 \uac10\uc5fc\uacfc \uac00\ub824\uc6c0\uc99d\uc744 \uc720\ubc1c\ud558\uac8c \ub429\ub2c8\ub2e4. \uadf8\ub798\uc11c \ub610\ub2e4\uc2dc \uac00\ub824\uc6c0\uc99d\uc774 \uc0dd\uae30\uac8c \ub418\uace0 \ub610 \ub2e4\uc2dc \uae01\uac8c \ub418\ub294 \uc545\uc21c\ud658 (vicious cycle)\uc5d0 \ub4e4\uc5b4\uac00\uac8c \ub418\uc5b4 \ud5e4\uc5b4\ub098\uae30 \ud798\ub4e0 \uc0c1\ud0dc\uc5d0 \ube60\uc9c0\uac8c \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n<div class=\"wp-block-media-text has-media-on-the-right is-stacked-on-mobile is-vertically-aligned-top\" style=\"grid-template-columns:auto 18%\"><div class=\"wp-block-media-text__content\">\n<p style=\"font-size:16px\">\uc6b0\ub9ac \uc2e4\ud5d8\uc2e4\uc5d0\uc11c\ub294 \uc911\uc694\ud55c \uac10\uac01 \uc911 \ud558\ub098\uc778 <span style=\"color: #008000;\"><strong>\uac00\ub824\uc6c0\uc99d (itch, pruritus)<\/strong><\/span>\uacfc \uc774\uc628 \ucc44\ub110 \ubc0f G protein-coupled receptor (GPCR)\uacfc\uc758 \uc0c1\uad00\uad00\uacc4\uc5d0 \ub300\ud558\uc5ec \ub2e4\uc591\ud55c \uc5f0\uad6c\ub97c \uc9c4\ud589\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uac00\ub824\uc6c0\uc99d\uc758 \ub300\ud45c\uc801\uc778 \uc9c8\ubcd1\uc73c\ub85c \uc544\ud1a0\ud53c\uc131 \ud53c\ubd80\uc5fc\uc744 \ub4e4 \uc218 \uc788\ub294\ub370, \ud658\uc790\uc758 \uc218\ub294 \ud574\ub9c8\ub2e4 \uc99d\uac00\ud558\uace0 \uc788\uc9c0\ub9cc, \ub9ce\uc740 \ud658\uc790\ub4e4\uc774 \ucc38\uc744 \uc218 \uc5c6\ub294 \uac00\ub824\uc6c0\uc99d\uc73c\ub85c \ud798\ub4e4\uc5b4 \ud558\ub294 \ub300\ud45c\uc801\uc778 \ub09c\uce58\uc131 \uc9c8\ud658\uc785\ub2c8\ub2e4. \ud639\uc790\ub294 \u201c\uc544\ud508 \uac83\uc740 \ucc38\uc544\ub3c4 \uac00\ub824\uc6b4 \uac83\uc740 \ubabb \ucc38\uaca0\ub2e4\u201d\ub294 \ub9d0\uc744 \uacf5\uacf5\uc5f0\ud558\uac8c \ud560 \uc815\ub3c4\ub85c \uadf9\uc2ec\ud55c \uac00\ub824\uc6c0\uc99d\uc740 \ud1b5\uc99d \uc774\uc0c1\uc758 \uace0\ud1b5\uc744 \ub3d9\ubc18\ud569\ub2c8\ub2e4. \uac00\ub824\uc6c0\uc99d\uc740 \ud56d\uc0c1 \uae01\ub294 \ud589\uc704\ub97c \ub3d9\ubc18\ud558\uac8c \ub418\ub294\ub370, \uadf9\uc2ec\ud55c \uac00\ub824\uc6c0\uc758 \uacbd\uc6b0 \uae01\ub294 \ud589\uc704\uac00 \ub2e8\uc9c0 \uac00\ub824\uc6c0\uc744 \uc77c\uc2dc\uc801\uc73c\ub85c \uc5c6\uc560\ub294 \uc791\uc6a9\uc5d0 \uba48\ucd94\uc9c0 \uc54a\uace0, \uc8fc\ubcc0 \ubd80\uc704\uc758 \uc0c1\ucc98\ub97c \ub3d9\ubc18\ud558\ub294 \ub4f1 \uc774\ucc28\uc801\uc778 \uac10\uc5fc\uacfc \uac00\ub824\uc6c0\uc99d\uc744 \uc720\ubc1c\ud558\uac8c \ub429\ub2c8\ub2e4. \uadf8\ub798\uc11c \ub610\ub2e4\uc2dc \uac00\ub824\uc6c0\uc99d\uc774 \uc0dd\uae30\uac8c \ub418\uace0 \ub610 \ub2e4\uc2dc \uae01\uac8c \ub418\ub294 \uc545\uc21c\ud658 (vicious cycle)\uc5d0 \ub4e4\uc5b4\uac00\uac8c \ub418\uc5b4 \ud5e4\uc5b4\ub098\uae30 \ud798\ub4e0 \uc0c1\ud0dc\uc5d0 \ube60\uc9c0\uac8c \ub429\ub2c8\ub2e4.<\/p>\n<\/div><figure class=\"wp-block-media-text__media\"><img decoding=\"async\" loading=\"lazy\" width=\"300\" height=\"225\" src=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/09\/scratch-300x225.png\" alt=\"\" class=\"wp-image-2996 size-medium\" srcset=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/09\/scratch-300x225.png 300w, https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/09\/scratch.png 720w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><\/figure><\/div>\n\n\n\n<p style=\"font-size:16px\">\uc548\ud0c0\uae5d\uac8c\ub3c4 \uac00\ub824\uc6c0\uc99d \uc644\ud654 \ubaa9\uc801\uc73c\ub85c \uc0ac\uc6a9\ud558\ub294 \uce58\ub8cc\uc81c\uc758 \ud6a8\uacfc\uac00 \uae30\ub300\uc5d0 \ubabb \ubbf8\uce58\uac70\ub098 \uc2ec\ud55c \ubd80\uc791\uc6a9\uc744 \ub3d9\ubc18\ud558\uae30 \ub54c\ubb38\uc5d0 \uc0c8\ub85c\uc6b4 \uac1c\ub150\uc758 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc774 \uc808\uc2e4\ud569\ub2c8\ub2e4. \uc55e\uc11c \uc124\uba85\ud558\uc600\ub4ef\uc774 \uac10\uac01\uacfc \uc774\uc628\ucc44\ub110\uc758 \uc0c1\uad00\uad00\uacc4\ub97c \ubc14\ud0d5\uc73c\ub85c \uac00\ub824\uc6c0\uc99d\uc5d0 \ub300\ud55c \uc791\uc6a9 \uae30\uc804\uc744 \uc774\ud574\ud558\uac8c \ub41c\ub2e4\uba74, \uc544\ud1a0\ud53c\uc131 \ud53c\ubd80\uc5fc\uacfc \uac19\uc740 \ub09c\uce58\uc131 \uac00\ub824\uc6c0\uc99d \uad00\ub828 \uc9c8\ubcd1\uc758 \uce58\ub8cc\uc5d0 \ud55c \ubc1c\uc790\uad6d \ub354 \ub2e4\uac00\uac08 \uc218 \uc788\uc744\uac70\ub77c \uc0dd\uac01\ud569\ub2c8\ub2e4.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uac10\uac01, \uc774\uc628 \ucc44\ub110, \uadf8\ub9ac\uace0 \uac00\ub824\uc6c0\uc99d \uc6b0\ub9ac \uc2e4\ud5d8\uc2e4\uc740 \uac00\ub824\uc6c0\uc99d\uc758 \ub2e4\uc591\ud55c \uce21\uba74 \uc911 \uc8fc\ub85c \uc2e0\uacbd\uacc4, \uadf8 \uc911\uc5d0\uc11c\ub3c4 \ub9d0\ucd08\uc2e0\uacbd\uacc4 (peripheral nervous system)\uc5d0\uc11c \ubc8c\uc5b4\uc9c0\ub294 \ub2e4\uc591\ud55c \ubd84\uc790 \uae30\uc804\uc744 \uaddc\uba85\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \uc5f0\uad6c\ub97c \uc218\ud589\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \uac10\uac01\uc740 \ub9d0\ucd08\uc2e0\uacbd\ub9d0\ub2e8\uc5d0\uc11c \uc804\uae30\uc801\uc778 \uc2e0\ud638\ub85c \ubcc0\ud654\ud558\uc5ec \ucc99\uc218(spinal cord)\ub97c \uc9c0\ub098 \ub1cc\uc758 \ud2b9\uc815 \uc601\uc5ed\uc5d0 \ub3c4\ub2ec\ud558\uac8c \ub418\uba70, \ucd5c\uc885\uc801\uc73c\ub85c \uc774\ub97c \uc778\uc9c0\ud558\uac8c \ub429\ub2c8\ub2e4. \uc9c0\uae08 \uc774 \uc21c\uac04\uc5d0\ub3c4 \ub2e4\uc591\ud55c \uae30\uacc4\uc801, \ubb3c\ub9ac\uc801, \ud654\ud559\uc801\uc778 \uc790\uadf9\ub4e4\uc740 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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