{"id":12,"date":"2012-07-24T18:09:32","date_gmt":"2012-07-24T09:09:32","guid":{"rendered":"http:\/\/misterx95.myds.me\/wordpress\/?p=12"},"modified":"2012-07-25T14:51:04","modified_gmt":"2012-07-25T05:51:04","slug":"2012-07-26","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=12","title":{"rendered":"Journal club 2012-07-26"},"content":{"rendered":"
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\r\n\t\r\n\t\t\"Emery.SOM\"\r\n\t<\/a>\r\n<\/dt>\r\n
\r\n\tFilename<\/strong> : emery-som.pdf<\/a> (907 KB)\r\n\t
\r\n\tCaption<\/strong> : \r\n<\/dd>\r\n<\/dl>
\r\n
\r\n\t\r\n\t\t\"Science-2011-Emery-1462-6\"\r\n\t<\/a>\r\n<\/dt>\r\n
\r\n\tFilename<\/strong> : science-2011-emery-1462-6.pdf<\/a> (426 KB)\r\n\t
\r\n\tCaption<\/strong> : \r\n<\/dd>\r\n<\/dl>

<\/p><\/div><\/div>\n

Science.<\/a>\u00a02011 Sep 9;333(6048):1462-6.<\/div>\n

HCN2\u00a0ion channels\u00a0play\u00a0a\u00a0central\u00a0role\u00a0in inflammatory and neuropathic pain.<\/h1>\n
Emery EC<\/a>,\u00a0Young GT<\/a>,\u00a0Berrocoso EM<\/a>,\u00a0Chen L<\/a>,\u00a0McNaughton PA<\/a>.<\/div>\n
\n

Source<\/h3>\n

Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK.<\/p>\n<\/div>\n

\n

Abstract<\/h3>\n

The rate of action potential firing in nociceptors is a major determinant of the intensity of pain. Possible modulators of action potential firing include the HCN\u00a0ion channels, which generate an inward current, I(h), after hyperpolarization of the membrane. We found that genetic deletion of\u00a0HCN2removed the cyclic adenosine monophosphate (cAMP)-sensitive component of I(h) and abolished action potential firing caused by an elevation of cAMP in nociceptors. Mice in which\u00a0HCN2\u00a0was specifically deleted in nociceptors expressing Na(V)1.8 had normal pain thresholds, but inflammation did not cause hyperalgesia to heat stimuli. After a nerve lesion, these mice showed no neuropathic pain in response to thermal or mechanical stimuli. Neuropathic pain is therefore initiated by\u00a0HCN2-driven action potential firing in Na(V)1.8-expressing nociceptors.<\/p>\n<\/div>\n

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PMID:<\/dt>\n<\/dl>\n

\u00a021903816<\/p>\n

[PubMed – indexed for MEDLINE]<\/p>\n

 <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Science.\u00a02011 Sep 9;333(6048):1462-6. HCN2\u00a0ion channels\u00a0play\u00a0a\u00a0central\u00a0role\u00a0in inflammatory and neuropathic pain. Emery EC,\u00a0Young GT,\u00a0Berrocoso EM,\u00a0Chen L,\u00a0McNaughton PA. Source Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK. Abstract The rate of action potential firing in nociceptors is a major determinant of the intensity of pain. Possible modulators of action potential firing include the HCN\u00a0ion channels, which […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/12"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=12"}],"version-history":[{"count":8,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/12\/revisions"}],"predecessor-version":[{"id":34,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/12\/revisions\/34"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=12"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=12"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=12"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}