{"id":1260,"date":"2016-07-08T10:31:54","date_gmt":"2016-07-08T01:31:54","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1260"},"modified":"2016-07-08T10:31:54","modified_gmt":"2016-07-08T01:31:54","slug":"journal-club-2016-7-8","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1260","title":{"rendered":"Journal Club 2016. 7. 8"},"content":{"rendered":"

TLR<\/span> signaling<\/span> adaptor<\/span> protein<\/span> MyD88<\/span> in primary<\/span> sensory<\/span> neurons<\/span> contributes<\/span> to persistent<\/span> inflammatory<\/span> and neuropathic<\/span> pain<\/span> and neuroinflammation<\/span>.<\/h1>\n
Liu XJ<\/span><\/a>1,<\/sup>2<\/sup><\/span>, Liu T<\/span><\/a>2,<\/sup>3<\/sup><\/span>, Chen G<\/span><\/a>2<\/span><\/sup>, Wang B<\/span><\/a>1<\/span><\/sup>, Yu XL<\/span><\/a>1<\/span><\/sup>, Yin C<\/span><\/a>1<\/span><\/sup>, Ji RR<\/span><\/a>2,<\/sup>4<\/sup><\/span>.<\/div>\n
\n

Abstract<\/h3>\n
\n

Increasing evidence suggests that neuro-immune and neuro-glial interactions are critically involved in chronic pain<\/span> sensitization. It is well studied how immune\/glial mediators sensitize pain<\/span>, but how sensory<\/span> neurons<\/span> control neuroinflammation<\/span> remains unclear. We employed Myd88<\/span> conditional knockout (CKO) mice, in which Myd88<\/span> was deleted in sodium channel subunit Nav1.8-expressing primary<\/span> sensory<\/span> neurons<\/span>, to examine the unique role of neuronal MyD88<\/span> in regulating acute and chronic pain<\/span>, and possible underlying mechanisms. We found that baseline pain<\/span> and the formalin induced acute inflammatory<\/span> pain<\/span> were intact in CKO mice. However, the late phase inflammatory<\/span> pain<\/span> following complete Freund’s adjuvant injection and the late phase neuropathic<\/span> pain<\/span> following chronic constriction injury (CCI), were reduced in CKO mice. CCI induced up-regulation of MyD88<\/span> and chemokine C-C motif ligand 2 expression in DRG neurons<\/span> and macrophage infiltration into DRGs, and microglia activation in spinal dorsal horns in wild-type mice, but all these changes were compromised in CKO mice. Finally, the pain<\/span> hypersensitivity induced by intraplantar IL-1\u03b2 was reduced in CKO mice. Our findings suggest that MyD88<\/span> in primary<\/span> sensory<\/span> neurons<\/span> plays an active role in regulating IL-1\u03b2 signaling<\/span> and neuroinflammation<\/span> in the peripheral and the central nervous systems, and contributes<\/span> to the maintenance of persistent<\/span> pain<\/span>.<\/p>\n

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

TLR signaling adaptor protein MyD88 in primary sensory neurons contributes to persistent inflammatory and neuropathic pain and neuroinflammation. Liu XJ1,2, Liu T2,3, Chen G2, Wang B1, Yu XL1, Yin C1, Ji RR2,4. Abstract Increasing evidence suggests that neuro-immune and neuro-glial interactions are critically involved in chronic pain sensitization. It is well studied how immune\/glial mediators […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1260"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1260"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1260\/revisions"}],"predecessor-version":[{"id":1261,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1260\/revisions\/1261"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}