{"id":1322,"date":"2016-10-28T10:30:42","date_gmt":"2016-10-28T01:30:42","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1322"},"modified":"2016-10-28T10:30:42","modified_gmt":"2016-10-28T01:30:42","slug":"journal-club-2016-10-28","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1322","title":{"rendered":"Journal Club 2016.10.28"},"content":{"rendered":"

TRPV1<\/span> is crucial<\/span> for proinflammatory STAT3<\/span> signaling and thermoregulation-associated pathways in the brain during inflammation.<\/h1>\n
Yoshida A<\/span><\/a>1<\/span><\/sup>, Furube E<\/span><\/a>1<\/span><\/sup>, Mannari T<\/span><\/a>1<\/span><\/sup>, Takayama Y<\/span><\/a>2<\/span><\/sup>, Kittaka H<\/span><\/a>2<\/span><\/sup>, Tominaga M<\/span><\/a>2<\/span><\/sup>, Miyata S<\/span><\/a>1<\/span><\/sup>.<\/div>\n
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Abstract<\/h3>\n<\/div>\n
\n
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Transient receptor potential vanilloid receptor 1 (TRPV1<\/span>) is a non-selective cation channel that is stimulated by heat (>43\u2009\u00b0C), mechanical\/osmotic stimuli, and low pH. The importance of TRPV1<\/span> in inflammatory responses has been demonstrated, whereas its participation in brains remains unclear. In the present study, the intracerebroventricular (icv) administration of the TRPV1<\/span> agonist resiniferatoxin (RTX) induced the activation of signal transducer and activator of transcription<\/span> 3 (STAT3<\/span>) in circumventricular organs (CVOs) and thermoregulation-associated brain regions with a similar patttern to the peripheral and icv administration of lipopolysaccharide (LPS). With the peripheral and icv LPS stimuli, STAT3<\/span> activation was significantly lower in Trpv1<\/span>(-\/-) mice than in Trpv1<\/span>(+\/+) mice. The icv administration of RTX induced transient hypothermia, whereas that of the TRPV1<\/span> antagonist capsazepine enhanced the magnitude and period of LPS-induced hyperthermia. These results indicate that TRPV1<\/span> is important for activating proinflammatory STAT3<\/span> signaling and thermoregulation-associated brain pathways in the brain.<\/p>\n<\/div>\n

TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation<\/a><\/p>\n<\/div>\n

supply_TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

TRPV1 is crucial for proinflammatory STAT3 signaling and thermoregulation-associated pathways in the brain during inflammation. Yoshida A1, Furube E1, Mannari T1, Takayama Y2, Kittaka H2, Tominaga M2, Miyata S1. Abstract Transient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel that is stimulated by heat (>43\u2009\u00b0C), mechanical\/osmotic stimuli, and low pH. The importance […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1322"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1322"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1322\/revisions"}],"predecessor-version":[{"id":1323,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1322\/revisions\/1323"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}