{"id":1361,"date":"2017-01-20T10:33:43","date_gmt":"2017-01-20T01:33:43","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1361"},"modified":"2017-01-20T10:33:43","modified_gmt":"2017-01-20T01:33:43","slug":"journal-club-2017-1-20","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1361","title":{"rendered":"Journal Club 2017. 1. 20"},"content":{"rendered":"

The transcription factor EPAS1 links DOCK8<\/span> deficiency to atopic skin inflammation via IL-31 induction.<\/h1>\n
Yamamura K<\/span><\/a>1,<\/sup>2<\/sup><\/span>, Uruno T<\/span><\/a>1,<\/sup>3<\/sup><\/span>, Shiraishi A<\/span><\/a>1<\/span><\/sup>, Tanaka Y<\/span><\/a>4<\/span><\/sup>, Ushijima M<\/span><\/a>1<\/span><\/sup>, Nakahara T<\/span><\/a>2<\/span><\/sup>, Watanabe M<\/span><\/a>1<\/span><\/sup>, Kido-Nakahara M<\/span><\/a>2<\/span><\/sup>, Tsuge I<\/span><\/a>5<\/span><\/sup>, Furue M<\/span><\/a>2<\/span><\/sup>, Fukui Y<\/span><\/a>1,<\/sup>3<\/sup><\/span>.<\/div>\n
\n

Abstract<\/h3>\n
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Mutations of DOCK8<\/span> in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. However, the molecular link between DOCK8<\/span> deficiency and atopic skin inflammation is unknown. Here we show that CD4+<\/span><\/sup> T cells from DOCK8<\/span>-deficient mice produce large amounts of IL-31, a major pruritogen associated with atopic dermatitis. IL-31 induction critically depends on the transcription factor EPAS1, and its conditional deletion in CD4+<\/span><\/sup> T cells abrogates skin disease development in DOCK8<\/span>-deficient mice. Although EPAS1 is known to form a complex with aryl hydrocarbon receptor nuclear translocator (ARNT) and control hypoxic responses, EPAS1-mediated Il31<\/span> promoter activation is independent of ARNT, but in collaboration with SP1. On the other hand, we find that DOCK8<\/span> is an adaptor and negative regulator of nuclear translocation of EPAS1. Thus, EPAS1 links DOCK8<\/span> deficiency to atopic skin inflammation via IL-31 induction in CD4+<\/span><\/sup> T cells.<\/p>\n<\/div>\n

the-transcription-factor-epas1-links-dock8-deficiency-to-atopic-skin-inflammation-via-il-31-induction<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Yamamura K1,2, Uruno T1,3, Shiraishi A1, Tanaka Y4, Ushijima M1, Nakahara T2, Watanabe M1, Kido-Nakahara M2, Tsuge I5, Furue M2, Fukui Y1,3. Abstract Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1361"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1361"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1361\/revisions"}],"predecessor-version":[{"id":1362,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1361\/revisions\/1362"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}