{"id":1379,"date":"2017-02-24T10:33:30","date_gmt":"2017-02-24T01:33:30","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1379"},"modified":"2017-02-24T10:33:30","modified_gmt":"2017-02-24T01:33:30","slug":"journal-club-2017-2-24","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1379","title":{"rendered":"Journal Club 2017. 2. 24"},"content":{"rendered":"

H2S<\/span> and NO cooperatively<\/span> regulate<\/span> vascular<\/span> tone<\/span> by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway.<\/h1>\n
Eberhardt M<\/span><\/a>1<\/span><\/sup>, Dux M<\/span><\/a>2<\/span><\/sup>, Namer B<\/span><\/a>3<\/span><\/sup>, Miljkovic J<\/span><\/a>4<\/span><\/sup>, Cordasic N<\/span><\/a>5<\/span><\/sup>, Will C<\/span><\/a>3<\/span><\/sup>, Kichko TI<\/span><\/a>3<\/span><\/sup>, de la Roche J<\/span><\/a>6<\/span><\/sup>, Fischer M<\/span><\/a>7<\/span><\/sup>, Su\u00e1rez SA<\/span><\/a>8<\/span><\/sup>, Bikiel D<\/span><\/a>8<\/span><\/sup>, Dorsch K<\/span><\/a>9<\/span><\/sup>, Leffler A<\/span><\/a>6<\/span><\/sup>, Babes A<\/span><\/a>10<\/span><\/sup>, Lampert A<\/span><\/a>11<\/span><\/sup>, Lennerz JK<\/span><\/a>9<\/span><\/sup>, Jacobi J<\/span><\/a>5<\/span><\/sup>, Mart\u00ed MA<\/span><\/a>12<\/span><\/sup>, Doctorovich F<\/span><\/a>8<\/span><\/sup>, H\u00f6gest\u00e4tt ED<\/span><\/a>13<\/span><\/sup>, Zygmunt PM<\/span><\/a>13<\/span><\/sup>, Ivanovic-Burmazovic I<\/span><\/a>4<\/span><\/sup>, Messlinger K<\/span><\/a>3<\/span><\/sup>, Reeh P<\/span><\/a>11<\/span><\/sup>, Filipovic MR<\/span><\/a>14<\/span><\/sup>.<\/div>\n
\n

Abstract<\/h3>\n
\n

Nitroxyl (HNO) is a redox sibling of nitric oxide (NO) that targets distinct signalling pathways with pharmacological endpoints of high significance in the treatment of heart failure. Beneficial HNO effects depend, in part, on its ability to release calcitonin gene-related peptide (CGRP) through an unidentified mechanism. Here we propose that HNO is generated as a result of the reaction of the two gasotransmitters NO and H2S<\/span>. We show that H2S<\/span> and NO production colocalizes with transient receptor potential channel A1 (TRPA1), and that HNO activates the sensory chemoreceptor channel TRPA1 via formation of amino-terminal disulphide bonds, which results in sustained calcium influx. As a consequence, CGRP is released, which induces local and systemic vasodilation. H2S<\/span>-evoked vasodilatatory effects largely depend on NO production and activation of HNO-TRPA1-CGRP pathway. We propose that this neuroendocrine HNO-TRPA1-CGRP signalling pathway constitutes an essential element for the control of vascular<\/span> tone<\/span> throughout the cardiovascular system.<\/p>\n<\/div>\n

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO\u2013TRPA1\u2013CGRP signalling pathway<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Eberhardt M1, Dux M2, Namer B3, Miljkovic J4, Cordasic N5, Will C3, Kichko TI3, de la Roche J6, Fischer M7, Su\u00e1rez SA8, Bikiel D8, Dorsch K9, Leffler A6, Babes A10, Lampert A11, Lennerz JK9, Jacobi J5, Mart\u00ed MA12, Doctorovich F8, H\u00f6gest\u00e4tt […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1379"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1379"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1379\/revisions"}],"predecessor-version":[{"id":1380,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1379\/revisions\/1380"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1379"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1379"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1379"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}