{"id":1403,"date":"2017-03-30T19:44:21","date_gmt":"2017-03-30T10:44:21","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1403"},"modified":"2017-03-30T19:44:21","modified_gmt":"2017-03-30T10:44:21","slug":"journal-club-2017-03-31","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1403","title":{"rendered":"Journal Club 2017. 03. 31"},"content":{"rendered":"

Leaky<\/span> Gate<\/span> Model<\/span>: Intensity-Dependent<\/span> Coding<\/span> of Pain and Itch in the Spinal Cord.<\/h1>\n
Sun S<\/span><\/a>1<\/span><\/sup>, Xu Q<\/span><\/a>1<\/span><\/sup>, Guo C<\/span><\/a>2<\/span><\/sup>, Guan Y<\/span><\/a>3<\/span><\/sup>, Liu Q<\/span><\/a>2<\/span><\/sup>, Dong X<\/span><\/a>4<\/span><\/sup>.<\/div>\n
\n

Abstract<\/h3>\n
\n

Coding<\/span> of itch versus pain has been heatedly debated for decades. However, the current coding<\/span> theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons. When activated, these Grp+<\/span><\/sup> neurons generated rarely seen, simultaneous robust pain and itch responses that were intensity dependent<\/span>. Accordingly, we propose a “leaky<\/span> gate<\/span>” model<\/span> in which Grp+<\/span><\/sup> neurons transmit both itch and weak pain signals; however, upon strong painful stimuli, the recruitment of endogenous opioids works to close this gate<\/span>, reducing overwhelming pain generated by parallel pathways. Consistent with our model<\/span>, loss of these Grp+<\/span><\/sup> neurons increased pain responses while itch was decreased. Our new model<\/span> serves as an example of non-monotonic coding<\/span> in the spinal cord and better explains observations in human psychophysical studies.<\/p>\n

total_Leaky Gate Model; Intensity-Dependent Coding of Pain and Itch in the Spinal Cord<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord. Sun S1, Xu Q1, Guo C2, Guan Y3, Liu Q2, Dong X4. Abstract Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1403"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1403"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1403\/revisions"}],"predecessor-version":[{"id":1404,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1403\/revisions\/1404"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1403"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1403"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1403"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}