{"id":1432,"date":"2017-05-18T19:08:59","date_gmt":"2017-05-18T10:08:59","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1432"},"modified":"2017-05-24T10:46:50","modified_gmt":"2017-05-24T01:46:50","slug":"2017-5-19-fri","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1432","title":{"rendered":"Journal Club 2017.05.19"},"content":{"rendered":"

The antimicrobial<\/span> peptide<\/span> hBD2<\/span> promotes<\/span> itch<\/span> through Toll-like<\/span> receptor<\/span> 4<\/span> signaling<\/span> in mice<\/span>.<\/h2>\n
Feng J<\/span><\/a>1<\/span><\/sup>, Luo J<\/span><\/a>1<\/span><\/sup>, Mack MR<\/span><\/a>2<\/span><\/sup>, Yang P<\/span><\/a>1<\/span><\/sup>, Zhang F<\/span><\/a>3<\/span><\/sup>, Wang G<\/span><\/a>3<\/span><\/sup>, Gong X<\/span><\/a>3<\/span><\/sup>, Cai T<\/span><\/a>4<\/span><\/span><\/sup>, Mei Z<\/span><\/a>3<\/span><\/sup>, Kim BS<\/span><\/a>2<\/span><\/sup>, Yin S<\/span><\/a>5<\/span><\/sup>, Hu H<\/span><\/a>6<\/span><\/sup>.<\/div>\n
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Abstract<\/h3>\n
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The psoriasis biomarker hBD2<\/span> produces a robust scratching response in a TLR4-dependent manner in mice<\/span>. TRPV1 is a downstream mediator of hBD2<\/span>-induced itch<\/span>. These findings suggest that hBD2<\/span> might act as an endogenous pruritogen in psoriatic itch<\/span>.<\/p>\n<\/div>\n<\/div>\n

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KEYWORDS:<\/h4>\n

CCR2; CCR6; TLR4; TRPA1; TRPV1; chronic itch<\/span>; human beta-defensin 2; psoriasis<\/p>\n<\/div>\n

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The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice<\/a><\/dt>\n<\/dl>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice. Feng J1, Luo J1, Mack MR2, Yang P1, Zhang F3, Wang G3, Gong X3, Cai T4, Mei Z3, Kim BS2, Yin S5, Hu H6. Abstract The psoriasis biomarker hBD2 produces a robust scratching response in a TLR4-dependent manner in mice. TRPV1 is […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1432"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1432"}],"version-history":[{"count":3,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1432\/revisions"}],"predecessor-version":[{"id":1437,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1432\/revisions\/1437"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1432"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1432"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1432"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}