{"id":1505,"date":"2017-09-01T08:36:33","date_gmt":"2017-08-31T23:36:33","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1505"},"modified":"2017-09-01T08:36:33","modified_gmt":"2017-08-31T23:36:33","slug":"2017-09-01","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1505","title":{"rendered":"2017.09.01"},"content":{"rendered":"

A\u00a0central<\/span>\u00a0neural<\/span>\u00a0circuit<\/span>\u00a0for\u00a0itch<\/span>\u00a0sensation<\/span>.<\/h1>\n
Mu D<\/a>1,<\/sup>2<\/sup>,\u00a0Deng J<\/a>1,<\/sup>2<\/sup>,\u00a0Liu KF<\/a>1<\/sup>,\u00a0Wu ZY<\/a>3<\/sup>,\u00a0Shi YF<\/a>1<\/sup>,\u00a0Guo WM<\/a>1<\/sup>,\u00a0Mao QQ<\/a>1<\/sup>,\u00a0Liu XJ<\/a>1<\/sup>,\u00a0Li H<\/a>3<\/sup>,\u00a0Sun YG<\/a>4<\/sup>.<\/div>\n
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<\/div>\n<\/div>\n
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Abstract<\/h3>\n
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Although\u00a0itch<\/span>\u00a0sensation<\/span>\u00a0is an important protective mechanism for animals, chronic\u00a0itch<\/span>\u00a0remains a challenging clinical problem.\u00a0Itch<\/span>\u00a0processing has been studied extensively at the spinal level. However, how\u00a0itch<\/span>\u00a0information is transmitted to the brain and what\u00a0central<\/span>\u00a0circuits underlie the\u00a0itch<\/span>-induced scratching behavior remain largely unknown. We found that the spinoparabrachial pathway was activated during\u00a0itch<\/span>processing and that optogenetic suppression of this pathway impaired\u00a0itch<\/span>-induced scratching behaviors.\u00a0Itch<\/span>-mediating spinal neurons, which express the gastrin-releasing peptide receptor, are disynaptically connected to the parabrachial nucleus via glutamatergic spinal projection neurons. Blockade of synaptic output of glutamatergic neurons in the parabrachial nucleus suppressed pruritogen-induced scratching behavior. Thus, our studies reveal a\u00a0central<\/span>\u00a0neural<\/span>\u00a0circuit<\/span>\u00a0that is critical for\u00a0itch<\/span>\u00a0signal processing.<\/p>\n

A central neural circuit for itch sensation.<\/a><\/p>\n

Supplementary materials for , A central neural circuit for itch sensation.<\/a><\/p>\n

Scratching behavior test by magnetic induction method.<\/p>\n

\nhttp:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2017\/09\/Recording-of-scratching-behaviour-with-magnetic-induction-method..mp4<\/a><\/video><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

A\u00a0central\u00a0neural\u00a0circuit\u00a0for\u00a0itch\u00a0sensation. Mu D1,2,\u00a0Deng J1,2,\u00a0Liu KF1,\u00a0Wu ZY3,\u00a0Shi YF1,\u00a0Guo WM1,\u00a0Mao QQ1,\u00a0Liu XJ1,\u00a0Li H3,\u00a0Sun YG4. Abstract Although\u00a0itch\u00a0sensation\u00a0is an important protective mechanism for animals, chronic\u00a0itch\u00a0remains a challenging clinical problem.\u00a0Itch\u00a0processing has been studied extensively at the spinal level. However, how\u00a0itch\u00a0information is transmitted to the brain and what\u00a0central\u00a0circuits underlie the\u00a0itch-induced scratching behavior remain largely unknown. We found that the spinoparabrachial pathway […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1505"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1505"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1505\/revisions"}],"predecessor-version":[{"id":1509,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1505\/revisions\/1509"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1505"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1505"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1505"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}