{"id":1568,"date":"2017-12-29T00:17:19","date_gmt":"2017-12-28T15:17:19","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1568"},"modified":"2017-12-29T00:17:19","modified_gmt":"2017-12-28T15:17:19","slug":"2017-12-29","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1568","title":{"rendered":"2017.12.29"},"content":{"rendered":"

Sensory<\/span>\u00a0TRP<\/span>\u00a0channels<\/span>\u00a0contribute<\/span>\u00a0differentially<\/span>\u00a0to\u00a0skin inflammation<\/span>\u00a0and\u00a0persistent<\/span>\u00a0itch<\/span>.<\/h1>\n
Feng J<\/a>1<\/sup>,\u00a0Yang P<\/a>1<\/sup>,\u00a0Mack MR<\/a>2<\/sup>,\u00a0Dryn D<\/a>1,<\/sup>3<\/sup>,\u00a0Luo J<\/a>1<\/sup>,\u00a0Gong X<\/a>1,<\/sup>4<\/sup>,\u00a0Liu S<\/a>1<\/sup>,\u00a0Oetjen LK<\/a>2<\/sup>,\u00a0Zholos AV<\/a>3<\/sup>,\u00a0Mei Z<\/a>4<\/sup>,\u00a0Yin S<\/a>4<\/sup>,\u00a0Kim BS<\/a>2<\/sup>,\u00a0Hu H<\/a>5<\/sup>.<\/div>\n
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<\/div>\n<\/div>\n
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Abstract<\/h3>\n
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Although both\u00a0persistent<\/span>\u00a0itch<\/span>\u00a0and\u00a0inflammation<\/span>\u00a0are commonly associated with allergic contact\u00a0dermatitis<\/span>\u00a0(ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1\u00a0channels<\/span>\u00a0are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1\u00a0channels<\/span>\u00a0protect the\u00a0skin inflammation<\/span>, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive\u00a0sensory<\/span>\u00a0nerves promotes cutaneous\u00a0inflammation<\/span>\u00a0in the SADBE-induced ACD. Our results demonstrate that\u00a0persistent<\/span>\u00a0itch<\/span>\u00a0and\u00a0inflammation<\/span>\u00a0are mediated by distinct cellular and molecular mechanisms in a mouse model of ACD. Identification of distinct roles of TRPA1 and TRPV1 in regulating\u00a0itch<\/span>\u00a0and\u00a0inflammation<\/span>\u00a0may provide new insights into the pathophysiology and treatment of chronic\u00a0itch<\/span>\u00a0and\u00a0inflammation<\/span>\u00a0in ACD patients.<\/p>\n

Sensory TRP channels contribute differentially to skin inflammation and persistent itch.<\/a><\/p>\n

Supplementary information<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Sensory\u00a0TRP\u00a0channels\u00a0contribute\u00a0differentially\u00a0to\u00a0skin inflammation\u00a0and\u00a0persistent\u00a0itch. Feng J1,\u00a0Yang P1,\u00a0Mack MR2,\u00a0Dryn D1,3,\u00a0Luo J1,\u00a0Gong X1,4,\u00a0Liu S1,\u00a0Oetjen LK2,\u00a0Zholos AV3,\u00a0Mei Z4,\u00a0Yin S4,\u00a0Kim BS2,\u00a0Hu H5. Abstract Although both\u00a0persistent\u00a0itch\u00a0and\u00a0inflammation\u00a0are commonly associated with allergic contact\u00a0dermatitis\u00a0(ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1\u00a0channels\u00a0are required for generating spontaneous scratching in a mouse model […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1568"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1568"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1568\/revisions"}],"predecessor-version":[{"id":1571,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1568\/revisions\/1571"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1568"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1568"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1568"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}