{"id":1582,"date":"2018-01-19T01:02:20","date_gmt":"2018-01-18T16:02:20","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1582"},"modified":"2018-01-19T01:02:20","modified_gmt":"2018-01-18T16:02:20","slug":"2018-01-19","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1582","title":{"rendered":"2018.01.19"},"content":{"rendered":"

Distinct roles of NMB and GRP in\u00a0itch<\/span>\u00a0transmission.<\/h1>\n
Wan L<\/a>1,<\/sup>2,<\/sup>3<\/sup>,\u00a0Jin H<\/a>1,<\/sup>2,<\/sup>4<\/sup>,\u00a0Liu XY<\/a>1,<\/sup>2<\/sup>,\u00a0Jeffry J<\/a>1,<\/sup>2<\/sup>,\u00a0Barry DM<\/a>1,<\/sup>2<\/sup>,\u00a0Shen KF<\/a>1,<\/sup>2,<\/sup>5<\/sup>,\u00a0Peng JH<\/a>1,<\/sup>2<\/sup>,\u00a0Liu XT<\/a>1,<\/sup>2,<\/sup>6<\/sup>,\u00a0Jin JH<\/a>1,<\/sup>2,<\/sup>7<\/sup>,\u00a0Sun Y<\/a>1,<\/sup>2,<\/sup>8<\/sup>,\u00a0Kim R<\/a>1<\/sup>,\u00a0Meng QT<\/a>1,<\/sup>2,<\/sup>9<\/sup>,\u00a0Mo P<\/a>1,<\/sup>2,<\/sup>10<\/sup>,\u00a0Yin J<\/a>1,<\/sup>2<\/sup>,\u00a0Tao A<\/a>6<\/sup>,\u00a0Bardoni R<\/a>11<\/sup>,\u00a0Chen ZF<\/a>12,<\/sup>13,<\/sup>14,<\/sup>15<\/sup>.<\/div>\n
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<\/div>\n<\/div>\n
\n

Abstract<\/h3>\n
\n

A key question in our understanding of\u00a0itch<\/span>\u00a0coding mechanisms is whether\u00a0itch<\/span>\u00a0is relayed by dedicated molecular and neuronal pathways. Previous studies suggested that gastrin-releasing peptide (GRP) is an\u00a0itch<\/span>-specific neurotransmitter. Neuromedin B (NMB) is a mammalian member of the bombesin family of peptides closely related to GRP, but its role in\u00a0itch<\/span>\u00a0is unclear. Here, we show that\u00a0itch<\/span>\u00a0deficits in\u00a0mice<\/span>lacking NMB or GRP are non-redundant and Nmb\/Grp double KO (DKO)\u00a0mice<\/span>\u00a0displayed additive deficits. Furthermore, both Nmb\/Grp and Nmbr\/Grpr DKO\u00a0mice<\/span>\u00a0responded normally to a wide array of noxious stimuli. Ablation of NMBR neurons partially attenuated peripherally induced\u00a0itch<\/span>\u00a0without compromising nociceptive processing. Importantly, electrophysiological studies suggested that GRPR neurons receive glutamatergic input from NMBR neurons. Thus, we propose that NMB and GRP may transmit discrete\u00a0itch<\/span>\u00a0information and NMBR neurons are an integral part of neural circuits for\u00a0itch<\/span>\u00a0in the spinal cord.<\/p>\n

Distinct roles of NMB and GRP in itch transmission.<\/a><\/p>\n

Supplementary information<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Distinct roles of NMB and GRP in\u00a0itch\u00a0transmission. Wan L1,2,3,\u00a0Jin H1,2,4,\u00a0Liu XY1,2,\u00a0Jeffry J1,2,\u00a0Barry DM1,2,\u00a0Shen KF1,2,5,\u00a0Peng JH1,2,\u00a0Liu XT1,2,6,\u00a0Jin JH1,2,7,\u00a0Sun Y1,2,8,\u00a0Kim R1,\u00a0Meng QT1,2,9,\u00a0Mo P1,2,10,\u00a0Yin J1,2,\u00a0Tao A6,\u00a0Bardoni R11,\u00a0Chen ZF12,13,14,15. Abstract A key question in our understanding of\u00a0itch\u00a0coding mechanisms is whether\u00a0itch\u00a0is relayed by dedicated molecular and neuronal pathways. Previous studies suggested that gastrin-releasing peptide (GRP) is an\u00a0itch-specific neurotransmitter. Neuromedin B […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1582"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1582"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1582\/revisions"}],"predecessor-version":[{"id":1585,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1582\/revisions\/1585"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}