{"id":1679,"date":"2018-10-05T13:38:21","date_gmt":"2018-10-05T04:38:21","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1679"},"modified":"2018-10-05T13:47:52","modified_gmt":"2018-10-05T04:47:52","slug":"matrine-inhibits-itching-by-lowering-the-activity-of-calcium-channel","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1679","title":{"rendered":"Matrine inhibits itching by lowering the activity of calcium channel"},"content":{"rendered":"

Sophorae Flavescentis Radix (SFR) is a medicinal herb with many functions that are involved in antiinflammation,\u00a0antinociception, and anticancer. SFR is also used to treat a variety of itching diseases.\u00a0Matrine (MT) is one of the main constituents in SFR and also has the effect of relieving itching, but the\u00a0antipruritic mechanism is still unclear. Here, we investigated the effect of MT on anti-pruritus. In acute\u00a0and chronic itch models, MT significantly inhibited the scratching behavior not only in acute itching\u00a0induced by histamine (His), chloroquine (CQ) and compound 48\/80 with a dose-depended manner, but\u00a0also in the chronic pruritus models of atopic dermatitis (AD) and acetone-ether-water (AEW) in mice.\u00a0Furthermore, MT could be detected in the blood after intraperitoneal injection (i.p.) and subcutaneous\u00a0injection (s.c.). Finally, electrophysiological and calcium imaging results showed that MT inhibited the\u00a0excitatory synaptic transmission from dorsal root ganglion (DRG) to the dorsal horn of the spinal cord
\nby suppressing the presynaptic N-type calcium channel. Taken together, we believe that MT is a novel\u00a0drug candidate in treating pruritus diseases, especially for histamine-independent and chronic pruritus,\u00a0which might be attributed to inhibition of the presynaptic N-type calcium channel.<\/p>\n

s41598-018-28661-x<\/a><\/p>\n

https:\/\/www.nature.com\/articles\/s41598-018-28661-x<\/p>\n","protected":false},"excerpt":{"rendered":"

Sophorae Flavescentis Radix (SFR) is a medicinal herb with many functions that are involved in antiinflammation,\u00a0antinociception, and anticancer. SFR is also used to treat a variety of itching diseases.\u00a0Matrine (MT) is one of the main constituents in SFR and also has the effect of relieving itching, but the\u00a0antipruritic mechanism is still unclear. Here, we investigated […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1679"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1679"}],"version-history":[{"count":4,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1679\/revisions"}],"predecessor-version":[{"id":1685,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1679\/revisions\/1685"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1679"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1679"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1679"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}