{"id":1742,"date":"2019-05-31T13:50:43","date_gmt":"2019-05-31T04:50:43","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=1742"},"modified":"2019-05-31T13:50:43","modified_gmt":"2019-05-31T04:50:43","slug":"2019-05-31","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=1742","title":{"rendered":"2019.05.31"},"content":{"rendered":"

Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis.<\/h1>\n
Williams MR<\/a>1<\/sup>,\u00a0Costa SK<\/a>2<\/sup>,\u00a0Zaramela LS<\/a>3<\/sup>,\u00a0Khalil S<\/a>1<\/sup>,\u00a0Todd DA<\/a>4<\/sup>,\u00a0Winter HL<\/a>4<\/sup>,\u00a0Sanford JA<\/a>1<\/sup>,\u00a0O’Neill AM<\/a>1<\/sup>,\u00a0Liggins MC<\/a>1<\/sup>,\u00a0Nakatsuji T<\/a>1<\/sup>,\u00a0Cech NB<\/a>4<\/sup>,\u00a0Cheung AL<\/a>2<\/sup>,\u00a0Zengler K<\/a>3,<\/sup>5,<\/sup>6<\/sup>,\u00a0Horswill AR<\/a>7,<\/sup>8<\/sup>,\u00a0Gallo RL<\/a>9,<\/sup>5<\/sup>.<\/div>\n
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Abstract<\/h3>\n
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Colonization of the skin by\u00a0Staphylococcus aureus<\/i>\u00a0is associated with exacerbation of atopic dermatitis (AD), but any direct mechanism through which dysbiosis of the skin microbiome may influence the development of AD is unknown. Here, we show that proteases and phenol-soluble modulin \u03b1 (PSM\u03b1) secreted by\u00a0S. aureus<\/i>\u00a0lead to endogenous epidermal proteolysis and skin barrier damage that promoted inflammation in mice. We further show that clinical isolates of different coagulase-negative staphylococci (CoNS) species residing on normal skin produced autoinducing peptides that inhibited the\u00a0S. aureus agr<\/i>\u00a0system, in turn decreasing PSM\u03b1 expression. These autoinducing peptides from skin microbiome CoNS species potently suppressed PSM\u03b1 expression in\u00a0S. aureus<\/i>\u00a0isolates from subjects with AD without inhibiting\u00a0S. aureus<\/i>\u00a0growth. Metagenomic analysis of the AD skin microbiome revealed that the increase in the relative abundance of\u00a0S. aureus<\/i>\u00a0in patients with active AD correlated with a lower CoNS autoinducing peptides to\u00a0S. aureus<\/i>\u00a0ratio, thus overcoming the peptides’ capacity to inhibit the\u00a0S. aureus agr<\/i>\u00a0system. Characterization of a\u00a0S. hominis<\/i>\u00a0clinical isolate identified an autoinducing peptide (SYNVCGGYF) as a highly potent inhibitor of\u00a0S. aureus agr<\/i>\u00a0activity, capable of preventing\u00a0S. aureus<\/i>-mediated epithelial damage and inflammation on murine skin. Together, these findings show how members of the normal human skin microbiome can contribute to epithelial barrier homeostasis by using quorum sensing to inhibit\u00a0S. aureus<\/i>\u00a0toxin production.<\/p>\n

2019_05_31<\/a><\/p>\n

2019_05_31_SS<\/a><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Quorum sensing between bacterial species on the skin protects against epidermal injury in atopic dermatitis. Williams MR1,\u00a0Costa SK2,\u00a0Zaramela LS3,\u00a0Khalil S1,\u00a0Todd DA4,\u00a0Winter HL4,\u00a0Sanford JA1,\u00a0O’Neill AM1,\u00a0Liggins MC1,\u00a0Nakatsuji T1,\u00a0Cech NB4,\u00a0Cheung AL2,\u00a0Zengler K3,5,6,\u00a0Horswill AR7,8,\u00a0Gallo RL9,5. Abstract Colonization of the skin by\u00a0Staphylococcus aureus\u00a0is associated with exacerbation of atopic dermatitis (AD), but any direct mechanism through which dysbiosis of the skin […]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1742"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1742"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1742\/revisions"}],"predecessor-version":[{"id":1745,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/1742\/revisions\/1745"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}