{"id":2267,"date":"2021-05-13T23:15:25","date_gmt":"2021-05-13T14:15:25","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=2267"},"modified":"2021-05-13T23:15:27","modified_gmt":"2021-05-13T14:15:27","slug":"journal-club-2021-05-13","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=2267","title":{"rendered":"Journal club 2021-05-13"},"content":{"rendered":"\n<p>Nat Commun.\u00a02020 Dec 11;11(1):6363.\u00a0doi: 10.1038\/s41467-020-19931-2.<\/p>\n\n\n\n<h1>Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system<\/h1>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chevalier+G&amp;cauthor_id=33311466\">Gr\u00e9goire Chevalier<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Siopi+E&amp;cauthor_id=33311466\">Eleni Siopi<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Guenin-Mac%C3%A9+L&amp;cauthor_id=33311466\">Laure Guenin-Mac\u00e9<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pascal+M&amp;cauthor_id=33311466\">Maud Pascal<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-1\">1<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Laval+T&amp;cauthor_id=33311466\">Thomas Laval<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rifflet+A&amp;cauthor_id=33311466\">Aline Rifflet<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Boneca+IG&amp;cauthor_id=33311466\">Ivo Gomperts Boneca<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Demangel+C&amp;cauthor_id=33311466\">Caroline Demangel<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Colsch+B&amp;cauthor_id=33311466\">Benoit Colsch<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Pruvost+A&amp;cauthor_id=33311466\">Alain Pruvost<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chu-Van+E&amp;cauthor_id=33311466\">Emeline Chu-Van<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Messager+A&amp;cauthor_id=33311466\">Aur\u00e9lie Messager<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Leulier+F&amp;cauthor_id=33311466\">Fran\u00e7ois Leulier<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lepousez+G&amp;cauthor_id=33311466\">Gabriel Lepousez<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Eberl+G&amp;cauthor_id=33311466\">G\u00e9rard Eberl<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-7\">7<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Lledo+PM&amp;cauthor_id=33311466\">Pierre-Marie Lledo<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33311466\/#affiliation-8\">8<\/a><\/sup><\/p>\n\n\n\n<ul id=\"full-view-identifiers\"><li>PMID:\u00a0<strong>33311466<\/strong><\/li><li>PMCID:\u00a0<a rel=\"noreferrer noopener\" target=\"_blank\" href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7732982\/\">PMC7732982<\/a><\/li><li>DOI:\u00a0<a rel=\"noreferrer noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1038\/s41467-020-19931-2\">10.1038\/s41467-020-19931-2<\/a><\/li><\/ul>\n\n\n\n<h2>Abstract<\/h2>\n\n\n\n<p>Depression is the leading cause of disability worldwide. Recent observations have revealed an association between mood disorders and alterations of the intestinal microbiota. Here, using unpredictable chronic mild stress (UCMS) as a mouse model of depression, we show that UCMS mice display phenotypic alterations, which could be transferred from UCMS donors to na\u00efve recipient mice by fecal microbiota transplantation. The cellular and behavioral alterations observed in recipient mice were accompanied by a decrease in the endocannabinoid (eCB) signaling due to lower peripheral levels of fatty acid precursors of eCB ligands. The adverse effects of UCMS-transferred microbiota were alleviated by selectively enhancing the central eCB or by complementation with a strain of the Lactobacilli genus. Our findings provide a mechanistic scenario for how chronic stress, diet and gut microbiota generate a pathological feed-forward loop that contributes to despair behavior via the central eCB system.<\/p>\n\n\n\n<div class=\"wp-block-file\"><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2021\/05\/s41467-020-19931-2.pdf\">s41467-020-19931-2<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2021\/05\/s41467-020-19931-2.pdf\" class=\"wp-block-file__button\" download>Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nat Commun.\u00a02020 Dec 11;11(1):6363.\u00a0doi: 10.1038\/s41467-020-19931-2. Effect of gut microbiota on depressive-like behaviors in mice is mediated by the endocannabinoid system Gr\u00e9goire Chevalier\u00a01,\u00a0Eleni Siopi\u00a02,\u00a0Laure Guenin-Mac\u00e9\u00a03,\u00a0Maud Pascal\u00a01\u00a02,\u00a0Thomas Laval\u00a03,\u00a0Aline Rifflet\u00a04,\u00a0Ivo Gomperts Boneca\u00a04,\u00a0Caroline Demangel\u00a03,\u00a0Benoit Colsch\u00a05,\u00a0Alain Pruvost\u00a05,\u00a0Emeline Chu-Van\u00a05,\u00a0Aur\u00e9lie Messager\u00a05,\u00a0Fran\u00e7ois Leulier\u00a06,\u00a0Gabriel Lepousez\u00a02,\u00a0G\u00e9rard Eberl\u00a07,\u00a0Pierre-Marie Lledo\u00a08 PMID:\u00a033311466 PMCID:\u00a0PMC7732982 DOI:\u00a010.1038\/s41467-020-19931-2 Abstract Depression is the leading cause of disability worldwide. Recent observations have revealed an [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2267"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2267"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2267\/revisions"}],"predecessor-version":[{"id":2269,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2267\/revisions\/2269"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2267"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2267"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2267"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}