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<\/a><\/figure>\n\n\n\nAbstract<\/h2>\n\n\n\nBackground<\/h3>\n\n\n\n
Chronic pruritus, or itch, is common and debilitating, but the neuro-immune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons. However, whether sensory neuron-restricted activity of IL-33 is necessary for chronic itch remains poorly understood.<\/p>\n\n\n\n
Objectives<\/h3>\n\n\n\n
We sought to determine if IL-33 signaling in sensory neurons is critical for the development of chronic itch in two divergent pruritic disease models.<\/p>\n\n\n\n
Methods<\/h3>\n\n\n\n
Plasma levels of IL-33 were assessed in patients with atopic dermatitis (AD) and chronic pruritus of unknown origin (CPUO). Mice were generated to conditionally delete IL-33R from sensory neurons. The contribution of neuronal IL-33R signaling to chronic itch development was tested in mouse models that recapitulate key pathologic features of AD and CPUO, respectively.<\/p>\n\n\n\n
Results<\/h3>\n\n\n\n
IL-33 was elevated in both AD and CPUO as well as their respective mouse models. While neuron-restricted IL-33R signaling was dispensable for itch in AD-like disease, it was required for the development of dry skin itch in a mouse model that mirrors key aspects of CPUO pathology.<\/p>\n\n\n\n
Conclusion<\/h3>\n\n\n\n
These data highlight how IL-33 may be a predominant mediator of itch in certain contexts, depending on the tissue microenvironment. Further, this study provides insight for future therapeutic strategies targeting the IL-33 pathway for chronic itch.<\/p>\n\n\n\n
Key Words<\/h2>\n\n\n\n- Atopic dermatitis<\/a><\/li>
- chronic pruritus of unknown origin<\/a><\/li>
- dry skin<\/a><\/li>
- IL-33<\/a><\/li>
- itch<\/a><\/li>
- neuroimmunology<\/a><\/li>
- pruriceptor<\/a><\/li>
- pruritogen<\/a><\/li><\/ul>\n\n\n\n
Abbreviations:<\/h4>\n\n\n\n
Ab<\/a> ((antibody)<\/a>), AD<\/a> ((atopic dermatitis)<\/a>), AEW<\/a> ((acetone\/ether plus water)<\/a>), bp<\/a> ((base pair)<\/a>), Cap<\/a> ((Capsaicin)<\/a>), CPUO<\/a> ((chronic pruritus of unknown origin)<\/a>), CQ<\/a> ((chloroquine)<\/a>), DRG<\/a> ((dorsal root ganglia)<\/a>), DT<\/a> ((diphtheria toxin)<\/a>), epidermis<\/a> ((Epi)<\/a>), EtOH<\/a> ((ethanol)<\/a>), HC<\/a> ((healthy control)<\/a>), His<\/a> ((histamine)<\/a>), i.d<\/a> ((intradermal)<\/a>), ILC2s<\/a> ((group 2 innate lymphoid cells)<\/a>), IL-33R<\/a> ((IL-33 receptor)<\/a>), i.p<\/a> ((intraperitoneal)<\/a>), KCl<\/a> ((potassium chloride)<\/a>), LM<\/a> ((littermate)<\/a>), loxP<\/a> ((locus of X-over P1)<\/a>), mAb<\/a> ((monoclonal antibody)<\/a>), MACS<\/a> ((magnetic-activated cell sorting)<\/a>), MasTRECK<\/a> ((mast cell-specific enhancer-mediated toxin receptor-mediated conditional cell knockout)<\/a>), NS<\/a> ((no significance)<\/a>), rh<\/a> ((recombinant human)<\/a>), rm<\/a> ((recombinant mouse)<\/a>), RNA-seq<\/a> ((RNA sequencing)<\/a>), stratum corneum<\/a> ((SC)<\/a>), Veh<\/a> ((Vehicle)<\/a>), WT<\/a> ((wild-type)<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch Abstract Background Chronic pruritus, or itch, is common and debilitating, but the neuro-immune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons. However, whether sensory neuron-restricted activity of IL-33 is necessary […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2394"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2394"}],"version-history":[{"count":2,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2394\/revisions"}],"predecessor-version":[{"id":2398,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2394\/revisions\/2398"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Abbreviations:<\/h4>\n\n\n\n
Ab<\/a> ((antibody)<\/a>), AD<\/a> ((atopic dermatitis)<\/a>), AEW<\/a> ((acetone\/ether plus water)<\/a>), bp<\/a> ((base pair)<\/a>), Cap<\/a> ((Capsaicin)<\/a>), CPUO<\/a> ((chronic pruritus of unknown origin)<\/a>), CQ<\/a> ((chloroquine)<\/a>), DRG<\/a> ((dorsal root ganglia)<\/a>), DT<\/a> ((diphtheria toxin)<\/a>), epidermis<\/a> ((Epi)<\/a>), EtOH<\/a> ((ethanol)<\/a>), HC<\/a> ((healthy control)<\/a>), His<\/a> ((histamine)<\/a>), i.d<\/a> ((intradermal)<\/a>), ILC2s<\/a> ((group 2 innate lymphoid cells)<\/a>), IL-33R<\/a> ((IL-33 receptor)<\/a>), i.p<\/a> ((intraperitoneal)<\/a>), KCl<\/a> ((potassium chloride)<\/a>), LM<\/a> ((littermate)<\/a>), loxP<\/a> ((locus of X-over P1)<\/a>), mAb<\/a> ((monoclonal antibody)<\/a>), MACS<\/a> ((magnetic-activated cell sorting)<\/a>), MasTRECK<\/a> ((mast cell-specific enhancer-mediated toxin receptor-mediated conditional cell knockout)<\/a>), NS<\/a> ((no significance)<\/a>), rh<\/a> ((recombinant human)<\/a>), rm<\/a> ((recombinant mouse)<\/a>), RNA-seq<\/a> ((RNA sequencing)<\/a>), stratum corneum<\/a> ((SC)<\/a>), Veh<\/a> ((Vehicle)<\/a>), WT<\/a> ((wild-type)<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":" IL-33 Signaling in Sensory Neurons Promotes Dry Skin Itch Abstract Background Chronic pruritus, or itch, is common and debilitating, but the neuro-immune mechanisms that drive chronic itch are only starting to be elucidated. Recent studies demonstrate that the IL-33 receptor (IL-33R) is expressed by sensory neurons. However, whether sensory neuron-restricted activity of IL-33 is necessary […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2394"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2394"}],"version-history":[{"count":2,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2394\/revisions"}],"predecessor-version":[{"id":2398,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2394\/revisions\/2398"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}