{"id":2456,"date":"2022-02-18T10:24:26","date_gmt":"2022-02-18T01:24:26","guid":{"rendered":"https:\/\/misterx95.myds.me\/?p=2456"},"modified":"2022-03-19T20:47:09","modified_gmt":"2022-03-19T11:47:09","slug":"sneezing-reflex-is-mediated-by-a-peptidergic-pathway-from-nose-to-brainstem","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=2456","title":{"rendered":"2022-02-18 Journal Club"},"content":{"rendered":"\n<p>Cell.&nbsp;2021 Jul 8;184(14):3762-3773.e10.&nbsp;doi: 10.1016\/j.cell.2021.05.017.&nbsp;Epub 2021 Jun 15.<\/p>\n\n\n\n<h1>Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem<\/h1>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Li+F&amp;cauthor_id=34133943\">Fengxian Li<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Jiang+H&amp;cauthor_id=34133943\">Haowu Jiang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Shen+X&amp;cauthor_id=34133943\">Xiaolei Shen<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Yang+W&amp;cauthor_id=34133943\">Weishan Yang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Guo+C&amp;cauthor_id=34133943\">Changxiong Guo<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Wang+Z&amp;cauthor_id=34133943\">Zhiyao Wang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Xiao+M&amp;cauthor_id=34133943\">Maolei Xiao<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Cui+L&amp;cauthor_id=34133943\">Lian Cui<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Luo+W&amp;cauthor_id=34133943\">Wenqin Luo<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Kim+BS&amp;cauthor_id=34133943\">Brian S Kim<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Chen+Z&amp;cauthor_id=34133943\">Zhoufeng Chen<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Huang+AJW&amp;cauthor_id=34133943\">Andrew J W Huang<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Liu+Q&amp;cauthor_id=34133943\">Qin Liu<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34133943\/#affiliation-6\">6<\/a><\/sup><\/p>\n\n\n\n<ul id=\"full-view-identifiers\"><li>PMID:&nbsp;<strong>34133943<\/strong><\/li><li>DOI:&nbsp;<a rel=\"noreferrer noopener\" target=\"_blank\" href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.05.017\">10.1016\/j.cell.2021.05.017<\/a><\/li><\/ul>\n\n\n\n<h2>Abstract<\/h2>\n\n\n\n<p>Sneezing is a vital respiratory reflex frequently associated with allergic rhinitis and viral respiratory infections. However, its neural circuit remains largely unknown. A sneeze-evoking region was discovered in both cat and human brainstems, corresponding anatomically to the central recipient zone of nasal sensory neurons. Therefore, we hypothesized that a neuronal population postsynaptic to nasal sensory neurons mediates sneezing in this region. By screening major presynaptic neurotransmitters\/neuropeptides released by nasal sensory neurons, we found that neuromedin B (NMB) peptide is essential for signaling sneezing. Ablation of NMB-sensitive postsynaptic neurons in the sneeze-evoking region or deficiency in NMB receptor abolished the sneezing reflex. Remarkably, NMB-sensitive neurons further project to the caudal ventral respiratory group (cVRG). Chemical activation of NMB-sensitive neurons elicits action potentials in cVRG neurons and leads to sneezing behavior. Our study delineates a peptidergic pathway mediating sneezing, providing molecular insights into the sneezing reflex arc.<\/p>\n\n\n\n<p><strong>Keywords:&nbsp;<\/strong>caudal ventral respiratory group; nasal sensory neurons; neuropeptide; sneeze; sneeze-evoking region.<\/p>\n\n\n\n<div class=\"wp-block-file\"><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2022\/02\/Sneezing-reflex.pdf\">Sneezing-reflex<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2022\/02\/Sneezing-reflex.pdf\" class=\"wp-block-file__button\" download>Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cell.&nbsp;2021 Jul 8;184(14):3762-3773.e10.&nbsp;doi: 10.1016\/j.cell.2021.05.017.&nbsp;Epub 2021 Jun 15. Sneezing reflex is mediated by a peptidergic pathway from nose to brainstem Fengxian Li\u00a01,\u00a0Haowu Jiang\u00a01,\u00a0Xiaolei Shen\u00a01,\u00a0Weishan Yang\u00a01,\u00a0Changxiong Guo\u00a01,\u00a0Zhiyao Wang\u00a01,\u00a0Maolei Xiao\u00a01,\u00a0Lian Cui\u00a02,\u00a0Wenqin Luo\u00a02,\u00a0Brian S Kim\u00a03,\u00a0Zhoufeng Chen\u00a04,\u00a0Andrew J W Huang\u00a05,\u00a0Qin Liu\u00a06 PMID:&nbsp;34133943 DOI:&nbsp;10.1016\/j.cell.2021.05.017 Abstract Sneezing is a vital respiratory reflex frequently associated with allergic rhinitis and viral respiratory infections. However, [&hellip;]<\/p>\n","protected":false},"author":11,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2456"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2456"}],"version-history":[{"count":3,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2456\/revisions"}],"predecessor-version":[{"id":2489,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2456\/revisions\/2489"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2456"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2456"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2456"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}