{"id":2799,"date":"2023-06-21T15:16:07","date_gmt":"2023-06-21T06:16:07","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=2799"},"modified":"2023-07-07T15:32:44","modified_gmt":"2023-07-07T06:32:44","slug":"journal-club-23-06-21","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=2799","title":{"rendered":"Journal Club \u2013 23.06.22"},"content":{"rendered":"\n<h2><strong>Sophorolipid inhibits histamine\u2010induced itch by decreasing PLC\/IP3R signaling pathway activation and modulating TRPV1 activity<\/strong><\/h2>\n\n\n\n<p><strong><br><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Xu+RQ&amp;cauthor_id=37198299\">Rui-Qi Xu<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37198299\/#full-view-affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Ma+L&amp;cauthor_id=37198299\">Ling Ma<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37198299\/#full-view-affiliation-2\">2<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Chen+T&amp;cauthor_id=37198299\">Timson Chen<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37198299\/#full-view-affiliation-3\">3<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Zhang+WX&amp;cauthor_id=37198299\">Wei-Xiong Zhang<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37198299\/#full-view-affiliation-3\">3<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Chang+K&amp;cauthor_id=37198299\">Kuan Chang<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37198299\/#full-view-affiliation-4\">4<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;term=Wang+J&amp;cauthor_id=37198299\">Jing Wang<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37198299\/#full-view-affiliation-5\">5<\/a><\/sup><\/strong><\/p>\n\n\n\n<ul><li><sup>1<\/sup>Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China.<\/li><li><sup>2<\/sup>Adolph Innovation Laboratory, Guangzhou Degu Personal Care Products Co., Ltd., Guangzhou, 510000, China. maling@adolph.cn.<\/li><li><sup>3<\/sup>Adolph Innovation Laboratory, Guangzhou Degu Personal Care Products Co., Ltd., Guangzhou, 510000, China.<\/li><li><sup>4<\/sup>Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China. changkuan@jiangnan.edu.cn.<\/li><li><sup>5<\/sup>Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China. jingwang@jiangnan.edu.cn.<\/li><\/ul>\n\n\n\n<p>Biosurfactants are attracting much interest due to their potential application as therapeutic agents in the medical and cosmetic field. Previous studies have demonstrated that biosurfactant such as sophorolipid (SL) exhibits immunomodulatory effects. In this article, we found the potential of sophorolipid for inhibiting histamine\u2010induced itch and preliminarily explored its molecular basis. First, behavioral tests indicated that SL can remit the histamine\u2010induced scratching behaviors of mice. Second, SL can suppress the the calcium influx induced by histamine, HTMT and VUF8430 in HaCaT cells. RT\u2010PCR analysis showed that the histamine\u2010induced upregulation of mRNA levels of phospholipase C\u03b31, 1,4,5\u2010trisphosphate receptor (IP3R), and protein kinase C\u03b1 can be inhibted by SL, suggesting that SL may impede the PLC\/IP3R signaling pathway activated by histamine. In further tests, the capsaicin\u2010induced calcium influx can also be inhibited by SL. The and molecular docking analysis indicated that SL acts as an inhibitor of transient receptor potential vanilloid\u20101 (TRPV1) activation to decrease calcium influx against stimuli. In summary, these results revealed that SL may inhibit histamine\u2010induced itch by decreasing PLC\/IP3R signaling pathway activation and modulating TRPV1 activity. This paper indicates that SL can be a useful treatment for histamine\u2010dependent itch.immunofluorescence<\/p>\n\n\n\n<div class=\"wp-block-file\"><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/06\/Sophorolipid-inhibits-histamine-induced-itch-by-decreasing-PLCIP3R-signaling-pathway-activation-and-modulating-TRPV1-activity.pdf\">Sophorolipid-inhibits-histamine-induced-itch-by-decreasing-PLCIP3R-signaling-pathway-activation-and-modulating-TRPV1-activity<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/06\/Sophorolipid-inhibits-histamine-induced-itch-by-decreasing-PLCIP3R-signaling-pathway-activation-and-modulating-TRPV1-activity.pdf\" class=\"wp-block-file__button\" download=\"\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sophorolipid inhibits histamine\u2010induced itch by decreasing PLC\/IP3R signaling pathway activation and modulating TRPV1 activity Rui-Qi Xu&nbsp;1,&nbsp;Ling Ma&nbsp;2,&nbsp;Timson Chen&nbsp;3,&nbsp;Wei-Xiong Zhang&nbsp;3,&nbsp;Kuan Chang&nbsp;4,&nbsp;Jing Wang&nbsp;5 1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China. 2Adolph Innovation Laboratory, Guangzhou Degu Personal Care Products Co., Ltd., Guangzhou, 510000, China. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2799"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2799"}],"version-history":[{"count":6,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2799\/revisions"}],"predecessor-version":[{"id":2813,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2799\/revisions\/2813"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}