{"id":2815,"date":"2023-07-11T10:24:59","date_gmt":"2023-07-11T01:24:59","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=2815"},"modified":"2023-07-11T10:25:00","modified_gmt":"2023-07-11T01:25:00","slug":"decreased-atp-synthesis-and-lower-ph-may-lead-to-abnormal-muscle-contraction-and-skin-sensitivity-in-human-skin","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=2815","title":{"rendered":"Decreased ATP synthesis and lower pH may lead to abnormal muscle contraction and skin sensitivity in human skin"},"content":{"rendered":"\n


Eun Ju\u00a0Kim\u00a0abc<\/sup>,\u00a0Dong Hun\u00a0Lee\u00a0abc<\/sup>,\u00a0Yeon Kyung\u00a0Kim\u00a0abc<\/sup>,\u00a0Min-Kyoung\u00a0Kim\u00a0abc<\/sup>,\u00a0Jung Yun\u00a0Kim\u00a0abc<\/sup>,\u00a0Min Jung\u00a0Lee\u00a0abc<\/sup>,\u00a0Won Woo\u00a0Choi\u00a0abc<\/sup>,\u00a0Hee Chul\u00a0Eun\u00a0abc<\/sup>,\u00a0Jin Ho\u00a0Chung\u00a0abc<\/sup><\/p>\n\n\n\n

Summary<\/h2>\n\n\n\n

Background<\/h3>\n\n\n\n

Sensitive skin represents hyperactive sensory symptoms showing exaggerated reactions in response to internal stimulants or external irritants. Although sensitive skin is a very common condition affecting an estimated 50% of the population, its pathophysiology remains largely elusive, particularly with regard to its metabolic aspects.<\/p>\n\n\n\n

Objective<\/h3>\n\n\n\n

The objective of our study was to investigate the pathogenesis of sensitive skin.<\/p>\n\n\n\n

Methods<\/h3>\n\n\n\n

We recruited healthy participants with \u2018sensitive\u2019 or \u2018non-sensitive\u2019 skin based on standardized questionnaires and 10% lactic acid stinging test, and obtained skin samples for microarray analysis and subsequent experiments.<\/p>\n\n\n\n

Results<\/h3>\n\n\n\n

Microarray transcriptome profiling revealed that genes involved in muscle contraction, carbohydrate and lipid metabolism, and ion transport and balance were significantly decreased in sensitive skin. These altered genes could account for the abnormal muscle contraction, decreased ATP amount in sensitive skin. In addition, pain-related transcripts such as TRPV1, ASIC3 and CGRP were significantly up-regulated in sensitive skin, compared with non-sensitive skin.<\/p>\n\n\n\n

Conclusions<\/h3>\n\n\n\n
Supplementary-Figure<\/a>Download<\/a><\/div>\n\n\n\n
Decreased-ATP-syntheis-and-lower-pH-may-lead-to-abnormal-muscle-contraction-and-skin-sensitivity-in-human-skin<\/a>Download<\/a><\/div>\n\n\n\n

Our findings suggest that sensitive skin is closely associated with the dysfunction of muscle contraction and metabolic homeostasis.<\/p>\n","protected":false},"excerpt":{"rendered":"

Eun Ju\u00a0Kim\u00a0abc,\u00a0Dong Hun\u00a0Lee\u00a0abc,\u00a0Yeon Kyung\u00a0Kim\u00a0abc,\u00a0Min-Kyoung\u00a0Kim\u00a0abc,\u00a0Jung Yun\u00a0Kim\u00a0abc,\u00a0Min Jung\u00a0Lee\u00a0abc,\u00a0Won Woo\u00a0Choi\u00a0abc,\u00a0Hee Chul\u00a0Eun\u00a0abc,\u00a0Jin Ho\u00a0Chung\u00a0abc Summary Background Sensitive skin represents hyperactive sensory symptoms showing exaggerated reactions in response to internal stimulants or external irritants. Although sensitive skin is a very common condition affecting an estimated 50% of the population, its pathophysiology remains largely elusive, particularly with regard to its metabolic aspects. […]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2815"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2815"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2815\/revisions"}],"predecessor-version":[{"id":2818,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/2815\/revisions\/2818"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2815"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2815"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2815"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}