{"id":3019,"date":"2023-09-22T10:32:45","date_gmt":"2023-09-22T01:32:45","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3019"},"modified":"2023-09-22T10:40:06","modified_gmt":"2023-09-22T01:40:06","slug":"journal-club-23-09-22","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3019","title":{"rendered":"Journal Club-23.09.22"},"content":{"rendered":"\n<h2>Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice<\/h2>\n\n\n\n<p>Jing Lei&nbsp;1,2,3, Reiko U. Yoshimoto&nbsp;4, Takeshi Matsui&nbsp;5,6,7, Masayuki Amagai5,7, Mizuho A. Kido&nbsp;4&nbsp;&amp; Makoto Tominaga&nbsp;1,2,3<\/p>\n\n\n\n<p>TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin kera- tinocytes, and participates in various somatic processes. Previous studies have reported that thermosensation in mice lacking TRPV3 was impaired. Here, we identified a transmembrane protein, TMEM79, that acts as a negative regulator of TRPV3. Heterologous expression of TMEM79 was capable of suppressing TRPV3-mediated currents in HEK293T cells. In addition, TMEM79 modulated TRPV3 translocalization and promoted its degradation in the lysosomes. TRPV3-mediated currents and Ca2+&nbsp;influx were potentiated in primary mouse keratinocytes lacking TMEM79. Furthermore, TMEM79-deficient male mice preferred a higher temperature than did wild-type mice due to elevated TRPV3 function. Our study revealed unique interactions between TRPV3 and TMEM79, both in vitro and in vivo. These&nbsp;findings support roles for TMEM79 and TRPV3 in thermosensation.<\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/09\/Involvement-of-skin-TRPV3-in-temperature-detection-regulated-by-TMEM79-in-mice.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Involvement-of-skin-TRPV3-in-temperature-detection-regulated-by-TMEM79-in-mice.\"><\/object><a id=\"wp-block-file--media-f03d2faa-acc5-450a-a4bd-485b5b6b652e\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/09\/Involvement-of-skin-TRPV3-in-temperature-detection-regulated-by-TMEM79-in-mice.pdf\">Involvement-of-skin-TRPV3-in-temperature-detection-regulated-by-TMEM79-in-mice<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2023\/09\/Involvement-of-skin-TRPV3-in-temperature-detection-regulated-by-TMEM79-in-mice.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-f03d2faa-acc5-450a-a4bd-485b5b6b652e\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice Jing Lei&nbsp;1,2,3, Reiko U. Yoshimoto&nbsp;4, Takeshi Matsui&nbsp;5,6,7, Masayuki Amagai5,7, Mizuho A. Kido&nbsp;4&nbsp;&amp; Makoto Tominaga&nbsp;1,2,3 TRPV3, a non-selective cation transient receptor potential (TRP) ion channel, is activated by warm temperatures. It is predominantly expressed in skin kera- tinocytes, and participates in various somatic processes. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[10,27],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3019"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3019"}],"version-history":[{"count":3,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3019\/revisions"}],"predecessor-version":[{"id":3023,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3019\/revisions\/3023"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}