{"id":3132,"date":"2024-03-23T14:42:57","date_gmt":"2024-03-23T05:42:57","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3132"},"modified":"2024-03-23T14:42:58","modified_gmt":"2024-03-23T05:42:58","slug":"journal-club-2024-03-22","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3132","title":{"rendered":"Journal club 2024.03.22"},"content":{"rendered":"\n<p>Pain.\u00a02024 Feb 28. \u00a0doi: 10.1097\/j.pain.0000000000003189.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=%22Pain%22%5Bjour%5D&amp;sort=date&amp;sort_order=desc\"><\/a><\/p>\n\n\n\n<h2>ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primate<\/h2>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Xie+MX&amp;cauthor_id=38422489\">Man-Xiu Xie<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-1\">1<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Rao+JH&amp;cauthor_id=38422489\">Jun-Hua Rao<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-2\">2<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Tian+XY&amp;cauthor_id=38422489\">Xiao-Yu Tian<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-3\">3<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Liu+JK&amp;cauthor_id=38422489\">Jin-Kun Liu<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-3\">3<\/a>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-4\">4<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Li+X&amp;cauthor_id=38422489\">Xiao Li<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chen+ZY&amp;cauthor_id=38422489\">Zi-Yi Chen<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Cao+Y&amp;cauthor_id=38422489\">Yan Cao<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-5\">5<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chen+AN&amp;cauthor_id=38422489\">An-Nan Chen<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-6\">6<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Shu+HH&amp;cauthor_id=38422489\">Hai-Hua Shu<\/a><sup>\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38422489\/#full-view-affiliation-7\">7<\/a><\/sup>,\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Zhang+XL&amp;cauthor_id=38422489\">Xiao-Long Zhang<\/a><sup>\u00a0<\/sup><\/p>\n\n\n\n<ul id=\"full-view-identifiers\">\n<li>PMID:&nbsp;<strong>38422489<\/strong><\/li>\n\n\n\n<li>DOI:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1097\/j.pain.0000000000003189\">10.1097\/j.pain.0000000000003189<\/a><\/li>\n<\/ul>\n\n\n\n<h4>Abstract<\/h4>\n\n\n\n<p>Acute and chronic itch are prevalent and incapacitating, yet the neural mechanisms underlying both acute and chronic itch are just starting to be unraveled. Activated transcription factor 4 (ATF4) belongs to the ATF\/CREB transcription factor family and primarily participates in the regulation of gene transcription. Our previous study has demonstrated that ATF4 is expressed in sensory neurons. Nevertheless, the role of ATF4 in itch sensation remains poorly understood. Here, we demonstrate that ATF4 plays a significant role in regulating itch sensation. The absence of ATF4 in dorsal root ganglion (DRG) neurons enhances the itch sensitivity of mice. Overexpression of ATF4 in sensory neurons significantly alleviates the acute and chronic pruritus in mice. Furthermore, ATF4 interacts with the transient receptor potential cation channel subfamily V member 4 (TRPV4) and inhibits its function without altering the expression or membrane trafficking of TRPV4 in sensory neurons. In addition, interference with ATF4 increases the itch sensitivity in nonhuman primates and enhances TRPV4 currents in nonhuman primates DRG neurons; ATF4 and TRPV4 also co-expresses in human sensory neurons. Our data demonstrate that ATF4 controls pruritus by regulating TRPV4 signaling through a nontranscriptional mechanism and identifies a potential new strategy for the treatment of pathological pruritus.<\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/03\/atf4_inhibits_trpv4_function_and_controls_itch.537.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of atf4_inhibits_trpv4_function_and_controls_itch.537.\"><\/object><a id=\"wp-block-file--media-f9378ab8-cc70-4f83-ad35-389344b79f6a\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/03\/atf4_inhibits_trpv4_function_and_controls_itch.537.pdf\">atf4_inhibits_trpv4_function_and_controls_itch.537<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/03\/atf4_inhibits_trpv4_function_and_controls_itch.537.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-f9378ab8-cc70-4f83-ad35-389344b79f6a\">Download<\/a><\/div>\n\n\n\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-0458ada6-d9d8-4cb8-b974-2693c6cfbd7b\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/03\/supplementary-data.pdf\">supplementary-data<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/03\/supplementary-data.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-0458ada6-d9d8-4cb8-b974-2693c6cfbd7b\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Pain.\u00a02024 Feb 28. \u00a0doi: 10.1097\/j.pain.0000000000003189. ATF4 inhibits TRPV4 function and controls itch perception in rodents and nonhuman primate Man-Xiu Xie\u00a01,\u00a0Jun-Hua Rao\u00a02,\u00a0Xiao-Yu Tian\u00a03,\u00a0Jin-Kun Liu\u00a03\u00a04,\u00a0Xiao Li\u00a05,\u00a0Zi-Yi Chen\u00a06,\u00a0Yan Cao\u00a05,\u00a0An-Nan Chen\u00a06,\u00a0Hai-Hua Shu\u00a07,\u00a0Xiao-Long Zhang\u00a0 Abstract Acute and chronic itch are prevalent and incapacitating, yet the neural mechanisms underlying both acute and chronic itch are just starting to be unraveled. Activated [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3132"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3132"}],"version-history":[{"count":2,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3132\/revisions"}],"predecessor-version":[{"id":3136,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3132\/revisions\/3136"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3132"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3132"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}