{"id":3187,"date":"2024-05-17T23:21:26","date_gmt":"2024-05-17T14:21:26","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3187"},"modified":"2024-05-17T23:23:25","modified_gmt":"2024-05-17T14:23:25","slug":"journal-club-2024-05-17-2","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3187","title":{"rendered":"<a href=\"https:\/\/misterx95.myds.me\/wordpress\/?p=3165\">Journal club: 2024.05.17<\/a>"},"content":{"rendered":"\n<p>Pain<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#\"><\/a>.\u00a02023 Jun 1; doi: 10.1097\/j.pain.0000000000002824.\u00a0<\/p>\n\n\n\n<h1>Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice<\/h1>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Furutani+K&amp;cauthor_id=36378290\">Kenta Furutani<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Chen+O&amp;cauthor_id=36378290\">Ouyang Chen<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-1\">1<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-2\">2<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=McGinnis+A&amp;cauthor_id=36378290\">Aidan McGinnis<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Wang+Y&amp;cauthor_id=36378290\">Yuqing Wang<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-1\">1<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Serhan+CN&amp;cauthor_id=36378290\">Charles N Serhan<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-3\">3<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Hansen+TV&amp;cauthor_id=36378290\">Trond Vidar Hansen<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-4\">4<\/a><\/sup>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Ji+RR&amp;cauthor_id=36378290\">Ru-Rong Ji<\/a><sup>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-1\">1<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-2\">2<\/a>&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36378290\/#full-view-affiliation-5\">5<\/a><\/sup><\/p>\n\n\n\n<p>Affiliations&nbsp;expand<\/p>\n\n\n\n<ul id=\"full-view-identifiers\">\n<li>PMID:&nbsp;<strong>36378290<\/strong><\/li>\n\n\n\n<li>PMCID:&nbsp;<strong>PMC10182233<\/strong>&nbsp;(available on&nbsp;2024-06-01)<\/li>\n\n\n\n<li>DOI:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1097\/j.pain.0000000000002824\">10.1097\/j.pain.0000000000002824<\/a><\/li>\n<\/ul>\n\n\n\n<h2>Abstract<\/h2>\n\n\n\n<p>Specialized proresolving mediators (SPMs) have demonstrated potent analgesic actions in animal models of pathological pain. The actions of SPMs in acute and chronic itch are currently unknown. Recently, n-3 docosapentaenoic acid (DPA) was found to be a substrate for the biosynthesis of several novel families of SPMs and 3-oxa-PD1 n-3 DPA (3-oxa-PD1) is an oxidation-resistant metabolic stable analogue of the n-3 DPA-derived protectin D1 (PD1). In this article, we demonstrate that 3-oxa-PD1 effectively reduces both acute and chronic itch in mouse models. Intrathecal injection of 3-oxa-PD1 (100 ng) reduced acute itch induced by histamine, chloroquine, or morphine. Furthermore, intrathecal 3-oxa-PD1 effectively reduced chronic itch, induced by cutaneous T-cell lymphoma (CTCL), allergic contact dermatitis with dinitrofluorobenzene, and psoriasis by imiquimod. Intratumoral injection of 3-oxa-PD1 also suppressed CTCL-induced chronic itch. Strikingly, the antipruritic effect lasted for several weeks after 1-week intrathecal 3-oxa-PD1 treatment. Whole-cell recordings revealed significant increase in excitatory postsynaptic currents in spinal dorsal horn (SDH) neurons of CTCL mice, but this increase was blocked by 3-oxa-PD1. 3-oxa-PD1 further increased inhibitory postsynaptic currents in SDH neurons of CTCL mice. Cutaneous T-cell lymphoma increased the spinal levels of lipocalin-2 (LCN2), an itch mediator produced by astrocytes. 3-oxa-PD1 suppressed LCN2 production in CTCL mice and LCN2 secretion in astrocytes. Finally, CTCL-induced anxiety was alleviated by intrathecal 3-oxa-PD1. Our findings suggest that 3-oxa-PD1 potently inhibits acute and chronic itch through the regulation of excitatory or inhibitory synaptic transmission and astroglial LCN2 production. Therefore, stable SPM analogs such as 3-oxa-PD1 could be useful to treat pruritus associated with different skin injuries.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pain.\u00a02023 Jun 1; doi: 10.1097\/j.pain.0000000000002824.\u00a0 Novel proresolving lipid mediator mimetic 3-oxa-PD1n-3 docosapentaenoic acid reduces acute and chronic itch by modulating excitatory and inhibitory synaptic transmission and astroglial secretion of lipocalin-2 in mice Kenta Furutani&nbsp;1,&nbsp;Ouyang Chen&nbsp;1&nbsp;2,&nbsp;Aidan McGinnis&nbsp;1,&nbsp;Yuqing Wang&nbsp;1,&nbsp;Charles N Serhan&nbsp;3,&nbsp;Trond Vidar Hansen&nbsp;4,&nbsp;Ru-Rong Ji&nbsp;1&nbsp;2&nbsp;5 Affiliations&nbsp;expand Abstract Specialized proresolving mediators (SPMs) have demonstrated potent analgesic actions in animal [&hellip;]<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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