{"id":3233,"date":"2024-08-08T17:57:53","date_gmt":"2024-08-08T08:57:53","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3233"},"modified":"2024-08-08T17:57:54","modified_gmt":"2024-08-08T08:57:54","slug":"journal-club-2024-08-09","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3233","title":{"rendered":"Journal Club 2024.08.09"},"content":{"rendered":"\n<h1 id=\"screen-reader-main-title\">Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch<\/h1>\n\n\n\n<p>Sonoko\u00a0Takahashi\u00a0<sup>113<\/sup>,\u00a0Sotaro\u00a0Ochiai\u00a0<sup>11013<\/sup> Jianshi\u00a0Jin\u00a0<sup>211<\/sup>,\u00a0Noriko\u00a0Takahashi\u00a0<sup>1<\/sup>,\u00a0Susumu\u00a0Toshima\u00a0<sup>13<\/sup>,\u00a0Harumichi\u00a0Ishigame\u00a0<sup>112<\/sup>,\u00a0Kenji\u00a0Kabashima\u00a0<sup>45<\/sup>,\u00a0Masato\u00a0Kubo\u00a0<sup>67<\/sup>,\u00a0Manabu\u00a0Nakayama\u00a0<sup>8<\/sup>,\u00a0Katsuyuki\u00a0Shiroguchi\u00a0<sup>2<\/sup>,\u00a0Takaharu\u00a0Okada\u00a0<sup>1914<\/sup><\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1016\/j.celrep.2023.113433\" target=\"_blank\">https:\/\/doi.org\/10.1016\/j.celrep.2023.113433<\/a><\/p>\n\n\n\n<h2>Highlights<\/h2>\n\n\n\n<ul>\n<li>Sensory neuronal IL-31RA and STAT3 are essential for IL-31-induced itch<\/li>\n\n\n\n<li>STAT3 is important for expression and downstream signaling of IL-31 receptor<\/li>\n\n\n\n<li>IL-31 enhances GPCR-induced itch transmitted by multiple sensory neuronal subsets<\/li>\n\n\n\n<li>Sensory neuronal STAT3 contributes to IL-31-independent inflammatory itch<\/li>\n<\/ul>\n\n\n\n<h2>Summary<\/h2>\n\n\n\n<p class=\"has-text-align-left\" id=\"abspara0010\">IL-31\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/receptor-blocking\">receptor blockade<\/a>\u00a0suppresses pruritus of\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/atopic-dermatitis\">atopic dermatitis<\/a>. However, cell-type-specific contributions of IL-31 receptor to itch, its expression mechanism, and the downstream\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/signal-transduction\">signaling pathway<\/a>\u00a0to induce itch remain unknown. Here, using conditional\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/knockout-mouse\">knockout mice<\/a>, we demonstrate that IL-31-induced itch requires sensory neuronal IL-31 receptor and\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/stat3\">STAT3<\/a>. We find that IL-31\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/receptor-expression\">receptor expression<\/a>\u00a0is dependent on\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/stat3\">STAT3<\/a>\u00a0in\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/neuroscience\/sensory-neuron\">sensory neurons<\/a>. In addition, pharmacological experiments suggest that\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/stat3\">STAT3<\/a>\u00a0activation is important for the itch-inducing signaling downstream of the IL-31 receptor. A cutaneous IL-31 injection induces the nuclear accumulation of activated STAT3 first in\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/sensory-neuron\">sensory neurons<\/a>\u00a0that abundantly express IL-31 receptor and then in other itch-transmitting neurons. IL-31 enhances itch induced by various pruritogens including even\u00a0<a href=\"https:\/\/www.sciencedirect.com\/topics\/immunology-and-microbiology\/chloroquine\">chloroquine<\/a>. Finally, pruritus associated with dermatitis is partially dependent on sensory neuronal IL-31 receptor and strongly on sensory neuronal STAT3. Thus, sensory neuronal STAT3 is essential for IL-31-induced itch and further contributes to IL-31-independent inflammatory itch.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-1.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"375\" height=\"375\" src=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-1.jpg\" alt=\"\" class=\"wp-image-3236\" srcset=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-1.jpg 375w, https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-1-300x300.jpg 300w, https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-1-150x150.jpg 150w\" sizes=\"(max-width: 375px) 100vw, 375px\" \/><\/a><figcaption class=\"wp-element-caption\">Graphical Abstract<\/figcaption><\/figure>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-STAT3-is-critical-for-IL-31-receptor-expression-and-inflammatory-itch.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Sensory-Neuronal-STAT3-is-critical-for-IL-31-receptor-expression-and-inflammatory-itch.\"><\/object><a id=\"wp-block-file--media-9335b65e-ce11-4b7b-9fc4-7cd0336007c8\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-STAT3-is-critical-for-IL-31-receptor-expression-and-inflammatory-itch.pdf\">Sensory-Neuronal-STAT3-is-critical-for-IL-31-receptor-expression-and-inflammatory-itch<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2024\/08\/Sensory-Neuronal-STAT3-is-critical-for-IL-31-receptor-expression-and-inflammatory-itch.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-9335b65e-ce11-4b7b-9fc4-7cd0336007c8\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch Sonoko\u00a0Takahashi\u00a0113,\u00a0Sotaro\u00a0Ochiai\u00a011013 Jianshi\u00a0Jin\u00a0211,\u00a0Noriko\u00a0Takahashi\u00a01,\u00a0Susumu\u00a0Toshima\u00a013,\u00a0Harumichi\u00a0Ishigame\u00a0112,\u00a0Kenji\u00a0Kabashima\u00a045,\u00a0Masato\u00a0Kubo\u00a067,\u00a0Manabu\u00a0Nakayama\u00a08,\u00a0Katsuyuki\u00a0Shiroguchi\u00a02,\u00a0Takaharu\u00a0Okada\u00a01914 https:\/\/doi.org\/10.1016\/j.celrep.2023.113433 Highlights Summary IL-31\u00a0receptor blockade\u00a0suppresses pruritus of\u00a0atopic dermatitis. However, cell-type-specific contributions of IL-31 receptor to itch, its expression mechanism, and the downstream\u00a0signaling pathway\u00a0to induce itch remain unknown. Here, using conditional\u00a0knockout mice, we demonstrate that IL-31-induced itch requires sensory neuronal IL-31 receptor [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3233"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3233"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3233\/revisions"}],"predecessor-version":[{"id":3237,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3233\/revisions\/3237"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3233"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3233"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3233"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}