{"id":3374,"date":"2025-02-28T10:10:15","date_gmt":"2025-02-28T01:10:15","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3374"},"modified":"2025-02-28T10:10:17","modified_gmt":"2025-02-28T01:10:17","slug":"journal-club-2025-02-28","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3374","title":{"rendered":"Journal club 2025.02.28"},"content":{"rendered":"\n

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation<\/strong><\/h2>\n\n\n\n

Andrew W. Liu1,2<\/sup>, Youran R. Zhang1,2<\/sup>, Chien-Sin Chen1,2<\/sup>, Tara N. Edwards1,2<\/sup>, Sumeyye Ozyaman1,2<\/sup>\u2020,
Torben Ramcke1,2<\/sup>, Lindsay M. McKendrick1,2<\/sup>, Eric S. Weiss1,2<\/sup>, Jacob E. Gillis1,2<\/sup>, Colin R. Laughlin2<\/sup>\u2021,
Simran K. Randhawa2<\/sup>, Catherine M. Phelps2<\/sup>, Kazuo Kurihara1,2<\/sup>, Hannah M. Kang1,2<\/sup>,
Sydney-Lam N. Nguyen1,2<\/sup>, Jiwon Kim3, Tayler D. Sheahan3\u00a7, Sarah E. Ross3,4, Marlies Meisel2,5<\/sup>,
Tina L. Sumpter1,2<\/sup>, Daniel H. Kaplan1,2<\/sup><\/strong>*<\/sup><\/p>\n\n\n\n

1<\/sup>Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA. 2<\/sup>Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. 3<\/sup>Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA. 4<\/sup>Pittsburgh Center for Pain Research, Pittsburgh, PA, USA. 5<\/sup>Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
*Corresponding author. Email: dankaplan@pitt.edu<\/strong>
\u2020Present address: Department of Histology and Embryology, School of Medicine, Istanbul Medipol University, Istanbul, Turkey.
\u2021Present address: Department of Immunobiology, Yale University, New Haven, CT, USA.
\u00a7Present address: Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI, USA.<\/p>\n\n\n\n

Editor\u2019s summary<\/h2>\n\n\n\n

Itch, the sensation that stimulates scratching behavior, is often triggered by skin irritants and inflammation. Liu et al<\/em>. found that ablating itch-sensing neurons or physically preventing scratching decreased the inflammation associated with antigen-dependent mast cell responses in response to chemicals that induce allergic immune responses (see the Perspective by Ver Heul). Scratching promoted pain-sensing neurons to release a neuropeptide that stimulated mast cells, and this peptide hormone synergized with antigen-dependent activation to increase the mast cell\u2019s degranulation and ability to produce inflammatory mediators. In a model of skin infection associated with antigen-specific mast cell responses, scratching contributed to decreasing the bacterial load. \u2014Sarah H. Ross<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n
<\/object>Scratching-promotes-allergic-inflammation-and-host-defense-via-neurogenic-mast-cell-activation<\/a>Download<\/a><\/div>\n\n\n\n
<\/object>Supplementary-figure..Scratching-promotes-allergic-inflammation-and-host-defense-via-neurogenic-mast-cell-activation<\/a>Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"

Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation Andrew W. Liu1,2, Youran R. Zhang1,2, Chien-Sin Chen1,2, Tara N. Edwards1,2, Sumeyye Ozyaman1,2\u2020,Torben Ramcke1,2, Lindsay M. McKendrick1,2, Eric S. Weiss1,2, Jacob E. Gillis1,2, Colin R. Laughlin2\u2021,Simran K. Randhawa2, Catherine M. Phelps2, Kazuo Kurihara1,2, Hannah M. Kang1,2,Sydney-Lam N. Nguyen1,2, Jiwon Kim3, Tayler D. Sheahan3\u00a7, […]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3374"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/14"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3374"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3374\/revisions"}],"predecessor-version":[{"id":3378,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3374\/revisions\/3378"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3374"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3374"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3374"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}