{"id":3397,"date":"2025-03-19T14:15:13","date_gmt":"2025-03-19T05:15:13","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3397"},"modified":"2025-03-19T14:15:15","modified_gmt":"2025-03-19T05:15:15","slug":"journal-club-2025-03-21","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3397","title":{"rendered":"Journal Club 2025.03.21"},"content":{"rendered":"\n<h2>Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop<\/h2>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.phymed.2025.156564\">https:\/\/doi.org\/10.1016\/j.phymed.2025.156564<\/a><\/p>\n\n\n\n<p>Yihan\u00a0Huang\u00a0<sup>a\u2020<\/sup>,\u00a0Na\u00a0Wang\u00a0<sup>b\u2020<\/sup>,\u00a0Xiaolan\u00a0Ji\u00a0<sup>a<\/sup>,\u00a0Shiqiong\u00a0Luo\u00a0<sup>a<\/sup>,\u00a0Ling\u00a0Gong\u00a0<sup>a<\/sup>,\u00a0Chenrui\u00a0Zhao\u00a0<sup>a<\/sup>,\u00a0Guodong\u00a0Zheng\u00a0<sup>a<\/sup>,\u00a0Rui\u00a0Liu\u00a0<sup>a<\/sup>,\u00a0Tao\u00a0Zhang\u00a0<sup>a<\/sup><\/p>\n\n\n\n<p><sup>a<\/sup>School of Pharmacy, Health Science Center, Xi&#8217;an Jiaotong University, Xi&#8217;an 710061, China<\/p>\n\n\n\n<p><sup>b<\/sup>Department of Otolaryngology, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China<\/p>\n\n\n\n<h2>Highlights<\/h2>\n\n\n\n<ul>\n<li>MrgprB2-mediated mast cell degranulation is critical for the persistence of inflammation in colitis.<\/li>\n\n\n\n<li>PAMP-MrgprB2-induced pro-inflammatory positive feedback loop is critical for inflammation.<\/li>\n\n\n\n<li>Apigenin reduces inflammatory symptoms and improves colon damage and inflammatory cell infiltration.<\/li>\n\n\n\n<li>Apigenin inhibited degranulation of mast cell and carboxypeptidase A3 levels.<\/li>\n\n\n\n<li>Apigenin ameliorating ulcerative colitis via MRGPRX2.<\/li>\n<\/ul>\n\n\n\n<h2>Keywords<\/h2>\n\n\n\n<p>Ulcerative colitis, Mast cells, Carboxypeptidase A3, Apigenin, MRGPRX2<\/p>\n\n\n\n<p><\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2025\/03\/Apigenin-ameliorates-inflamed-ulcerative-colitis-by-regulating-mast-cell-degranulation-via-the-PAMP-MRGPRX2-feedback-loop-1.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Apigenin-ameliorates-inflamed-ulcerative-colitis-by-regulating-mast-cell-degranulation-via-the-PAMP-MRGPRX2-feedback-loop-1.\"><\/object><a id=\"wp-block-file--media-a06f8578-0c9d-4547-b3a2-7e205a99bd7b\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2025\/03\/Apigenin-ameliorates-inflamed-ulcerative-colitis-by-regulating-mast-cell-degranulation-via-the-PAMP-MRGPRX2-feedback-loop-1.pdf\">Apigenin-ameliorates-inflamed-ulcerative-colitis-by-regulating-mast-cell-degranulation-via-the-PAMP-MRGPRX2-feedback-loop-1<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2025\/03\/Apigenin-ameliorates-inflamed-ulcerative-colitis-by-regulating-mast-cell-degranulation-via-the-PAMP-MRGPRX2-feedback-loop-1.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-a06f8578-0c9d-4547-b3a2-7e205a99bd7b\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop https:\/\/doi.org\/10.1016\/j.phymed.2025.156564 Yihan\u00a0Huang\u00a0a\u2020,\u00a0Na\u00a0Wang\u00a0b\u2020,\u00a0Xiaolan\u00a0Ji\u00a0a,\u00a0Shiqiong\u00a0Luo\u00a0a,\u00a0Ling\u00a0Gong\u00a0a,\u00a0Chenrui\u00a0Zhao\u00a0a,\u00a0Guodong\u00a0Zheng\u00a0a,\u00a0Rui\u00a0Liu\u00a0a,\u00a0Tao\u00a0Zhang\u00a0a aSchool of Pharmacy, Health Science Center, Xi&#8217;an Jiaotong University, Xi&#8217;an 710061, China bDepartment of Otolaryngology, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China Highlights Keywords Ulcerative colitis, Mast cells, Carboxypeptidase A3, Apigenin, MRGPRX2<\/p>\n","protected":false},"author":20,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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