{"id":3475,"date":"2025-07-04T10:33:41","date_gmt":"2025-07-04T01:33:41","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3475"},"modified":"2025-07-04T10:59:32","modified_gmt":"2025-07-04T01:59:32","slug":"journal-club-25-07-04","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3475","title":{"rendered":"Journal Club 25-07-04"},"content":{"rendered":"\n

Involvement of \u03b1-Melanocyte\u2013Stimulating Hormone\u2013Thromboxane A2<\/sub> System on Itching in Atopic Dermatitis<\/h2>\n\n\n\n

Tsugunobu Andoh \u2217<\/sup>, Chihiro Akasaka \u2217<\/sup>, Kyoko Shimizu \u2020<\/sup>, Jung-Bum Lee \u2021<\/sup>, Yoko Yoshihisa \u2020<\/sup>, Tadamichi Shimizu \u2020<\/sup><\/p>\n\n\n\n

\u2217<\/sup>Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan<\/p>\n\n\n\n

\u2020<\/sup>Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan<\/p>\n\n\n\n

\u2021<\/sup>Laboratory of Medicinal Bio-resources, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan<\/p>\n\n\n\n

https:\/\/doi.org\/10.1016\/j.ajpath.2019.05.017<\/a><\/p>\n\n\n\n

\u03b1-Melanocyte\u2013stimulating hormone (\u03b1-MSH) is an endogenous peptide hormone<\/a> involved in cutaneous pigmentation in atopic dermatitis<\/a> (AD) with severe itching. \u03b1-MSH elicits itch-related responses in mice. We, therefore, investigated whether \u03b1-MSH was involved in itching in AD. In the skin of AD patients and mice with atopy-like dermatitis, \u03b1-MSH and the prohormone convertase 2<\/a>, which is the key processing enzyme for the production of \u03b1-MSH, were distributed mainly in keratinocytes. In the skin of mice with dermatitis, melanocortin receptors<\/a> (MC1R and MC5R) were expressed at the mRNA level and were distributed in the dermis. In the dorsal root ganglion of mice with dermatitis, mRNAs encoding MC1R, MC3R, and MC5R were also expressed. MC1R antagonist agouti-signaling protein inhibited spontaneous scratching in mice with dermatitis. In healthy mice, intradermal \u03b1-MSH elicited itch-associated responses, which were inhibited by thromboxane (TX) A2<\/sub> receptor antagonist ONO-3708. In mouse keratinocytes, \u03b1-MSH increased the production of TXA2<\/sub>, which was inhibited by adenylyl cyclase inhibitor<\/a> SQ-22536 and Ca2+<\/sup>chelator<\/a>EGTA<\/a>. In mouse keratinocytes treated with siRNA<\/a> for MC1R and\/or MC5R, \u03b1-MSH\u2013induced TXA2<\/sub> production was decreased. \u03b1-MSH increased intracellular Ca2+<\/sup> ion concentration in dorsal root ganglion neurons and keratinocytes. These results suggest that \u03b1-MSH is involved in itching during AD and may elicit itching through the direct action of primary afferents and TXA2<\/sub> production by keratinocytes.<\/p>\n\n\n\n

<\/object>Involvement-of-alpha-Melanocyte-Stimulating-Hormone-Thromboxane-A2-System-on-Itching-in-Atopic-Dermatitis<\/a>Download<\/a><\/div>\n\n\n\n

<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Involvement of \u03b1-Melanocyte\u2013Stimulating Hormone\u2013Thromboxane A2 System on Itching in Atopic Dermatitis Tsugunobu Andoh \u2217, Chihiro Akasaka \u2217, Kyoko Shimizu \u2020, Jung-Bum Lee \u2021, Yoko Yoshihisa \u2020, Tadamichi Shimizu \u2020 \u2217Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan \u2020Department of Dermatology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan \u2021Laboratory of Medicinal Bio-resources, Graduate School of Medicine and Pharmaceutical Sciences, University of […]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3475"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/22"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3475"}],"version-history":[{"count":5,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3475\/revisions"}],"predecessor-version":[{"id":3484,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3475\/revisions\/3484"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3475"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3475"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3475"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}