{"id":3624,"date":"2026-01-26T00:25:56","date_gmt":"2026-01-25T15:25:56","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3624"},"modified":"2026-01-26T00:25:57","modified_gmt":"2026-01-25T15:25:57","slug":"journal-club-26-01-26","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3624","title":{"rendered":"Journal club: 26.01.26"},"content":{"rendered":"\n<h1><strong>Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice<\/strong><\/h1>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Hyoung_Gon-Ko-Aff1-Aff2\">Hyoung-Gon Ko<\/a><sup>1,2<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Hyunsu-Jung-Aff3-Aff4\">Hyunsu Jung<\/a><sup>#3,4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Seunghyo-Han-Aff1\">Seunghyo Han<\/a><sup>#5<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Dong_Il-Choi-Aff4\">Dong Il Choi<\/a><sup>#4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Chiwoo-Lee-Aff4\">Chiwoo Lee<\/a><sup>#4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Ja_Eun-Choi-Aff4\">Ja Eun Choi<\/a><sup>4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Jihae-Oh-Aff4\">Jihae Oh<\/a><sup>4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Chuljung-Kwak-Aff3\">Chuljung Kwak<\/a><sup>3<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Dae_Hee-Han-Aff3\">Dae Hee Han<\/a><sup>3<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Jun_Nyeong-Kim-Aff1\">Jun-Nyeong Kim<\/a><sup>5<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Sanghyun-Ye-Aff4\">Sanghyun Ye<\/a><sup>4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Jiah-Lee-Aff4\">Jiah Lee<\/a><sup>4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Jaehyun-Lee-Aff4\">Jaehyun Lee<\/a><sup>4<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Kyungmin-Lee-Aff5\">Kyungmin Lee<\/a><sup>6<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Jae_Hyung-Lee-Aff6\">Jae-Hyung Lee<\/a><sup>7<\/sup>,\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Min-Zhuo-Aff7-Aff8\">Min Zhuo<\/a><sup>8,9<\/sup>\u00a0&amp;\u00a0 <a href=\"https:\/\/www.nature.com\/articles\/s41467-025-57041-z#auth-Bong_Kiun-Kaang-Aff3-Aff4\">Bong-Kiun Kaang<\/a><sup>10,11<\/sup><\/p>\n\n\n\n<p><sup>1<\/sup>Department of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, 2177 Dalgubeol-daero, Daegu, South Korea. hgko@khu.ac.kr.<sup>2<\/sup>Department of Oral Anatomy and Developmental Biology, Kyung Hee University College of Dentistry, Seoul, South Korea. hgko@khu.ac.kr.<sup>3<\/sup>Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, 34126, South Korea.<sup>4<\/sup>Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul, South Korea.<sup>5<\/sup>Department of Anatomy and Neurobiology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, 2177 Dalgubeol-daero, Daegu, South Korea.<sup>6<\/sup>Laboratory for Behavioral Neural Circuitry and Physiology, Department of Anatomy, Brain Science and Engineering Institute, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Daegu, South Korea.<sup>7<\/sup>Department of Oral Microbiology, College of Dentistry, Kyung Hee University, 26 Kyungheedae-ro, Seoul, South Korea.<sup>8<\/sup>Department of Physiology, Faculty of Medicine, University of Toronto, 1 King&#8217;s College Circle, Toronto, Ontario, Canada.<sup>9<\/sup>International Institute for Brain Research, Qingdao International Academician Park, Qingdao, China.<sup>10<\/sup>Center for Cognition and Sociality, Institute for Basic Science (IBS), Daejeon, 34126, South Korea. kaang@ibs.re.kr.<sup>11<\/sup>Department of Biological Sciences, College of Natural Sciences, Seoul National University, 1 Gwanangno, Seoul, South Korea. kaang@ibs.re.kr.<sup>#<\/sup>Contributed equally.<\/p>\n\n\n\n<ul id=\"full-view-identifiers\">\n<li>PMID:&nbsp;<strong>40038260<\/strong><\/li>\n\n\n\n<li>PMCID:&nbsp;<a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11880300\/\">PMC11880300<\/a><\/li>\n\n\n\n<li>DOI:\u00a0<a rel=\"noreferrer noopener\" href=\"https:\/\/doi.org\/10.1038\/s41467-025-57041-z\" target=\"_blank\">10.1038\/s41467-025-57041-z<\/a>\n<ul>\n<li><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 id=\"Abs1\">Abstract<\/h2>\n\n\n\n<p>Pain and itch are aversive sensations with distinct qualities, processed in overlapping pathways and brain regions, including the anterior cingulate cortex (ACC), which is critical for their affective dimensions. However, the cellular mechanisms underlying their processing in the ACC remain unclear. Here, we identify modality-specific neuronal populations in layer II\/III of the ACC in mice involved in pain and itch processing. Using a synapse labeling tool, we show that pain- and itch-related neurons selectively receive synaptic inputs from mediodorsal thalamic neurons activated by pain and itch stimuli, respectively. Chemogenetic inhibition of these neurons reduced pruriception or nociception without affecting the opposite modality. Conversely, activation of these neurons did not enhance stimulus-specific responses but commonly increased freezing-like behavior. These findings reveal that the processing of itch and pain information in the ACC involves activity-dependent and modality-specific neuronal populations, and that pain and itch are processed by functionally distinct ACC neuronal subsets.<\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Processing-of-pain-and-itch-information-by-modality-specific-neurons-within-the-anterior-cingulate-cortex-in-mice.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Processing-of-pain-and-itch-information-by-modality-specific-neurons-within-the-anterior-cingulate-cortex-in-mice.\"><\/object><a id=\"wp-block-file--media-2e496382-1d33-4599-97e4-71940f336aae\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Processing-of-pain-and-itch-information-by-modality-specific-neurons-within-the-anterior-cingulate-cortex-in-mice.pdf\">Processing-of-pain-and-itch-information-by-modality-specific-neurons-within-the-anterior-cingulate-cortex-in-mice<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Processing-of-pain-and-itch-information-by-modality-specific-neurons-within-the-anterior-cingulate-cortex-in-mice.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-2e496382-1d33-4599-97e4-71940f336aae\">Download<\/a><\/div>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Supplementary-information.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Supplementary-information.\"><\/object><a id=\"wp-block-file--media-91586644-131f-4a3b-abe6-41215c5c2d59\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Supplementary-information.pdf\">Supplementary-information<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Supplementary-information.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-91586644-131f-4a3b-abe6-41215c5c2d59\">Download<\/a><\/div>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Peer-review-file.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of Peer-review-file.\"><\/object><a id=\"wp-block-file--media-6273d22f-8bdd-4a4e-b439-39c45f88a81c\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Peer-review-file.pdf\">Peer-review-file<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/01\/Peer-review-file.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-6273d22f-8bdd-4a4e-b439-39c45f88a81c\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Processing of pain and itch information by modality-specific neurons within the anterior cingulate cortex in mice Hyoung-Gon Ko1,2,\u00a0 Hyunsu Jung#3,4,\u00a0 Seunghyo Han#5,\u00a0 Dong Il Choi#4,\u00a0 Chiwoo Lee#4,\u00a0 Ja Eun Choi4,\u00a0 Jihae Oh4,\u00a0 Chuljung Kwak3,\u00a0 Dae Hee Han3,\u00a0 Jun-Nyeong Kim5,\u00a0 Sanghyun Ye4,\u00a0 Jiah Lee4,\u00a0 Jaehyun Lee4,\u00a0 Kyungmin Lee6,\u00a0 Jae-Hyung Lee7,\u00a0 Min Zhuo8,9\u00a0&amp;\u00a0 Bong-Kiun Kaang10,11 1Department of [&hellip;]<\/p>\n","protected":false},"author":14,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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