{"id":3757,"date":"2026-06-18T21:35:57","date_gmt":"2026-06-18T12:35:57","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3757"},"modified":"2026-06-18T21:36:40","modified_gmt":"2026-06-18T12:36:40","slug":"journal-club-2026-06-18","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3757","title":{"rendered":"Journal Club 2026.06.18"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<h2>Psychological stress delays inflammatory resolution and promotes sustained sensory sensitization during recovery from atopic dermatitis<\/h2>\n\n\n\n<p>Qiaofeng Zhao, Alberto Leguina-Ruzzi, Mitsutoshi Tominaga, Yayoi Kamata, Atsuko Kamo, Huiying Wan, Yuping Ran, Kenji Takamori<\/p>\n\n\n\n<p>Atopic dermatitis (AD) is a chronic inflammatory disorder characterized by pruritus, eczematous<br>lesions, and epidermal barrier dysfunction, with substantial impact on quality of life (Weidinger<br>and Novak 2016). Its pathogenesis reflects a complex interplay between barrier impairment,<br>immune dysregulation, and environmental triggers, resulting in heterogeneous phenotypes (Kim,<br>Kim et al. 2019). While mechanisms driving onset and exacerbation have been extensively studied,<br>the processes governing disease resolution remain poorly understood. Inflammatory resolution is<br>increasingly recognized as an active process involving immune reprogramming, tissue repair, and<br>restoration of homeostasis rather than a passive decline in inflammation (Oetjen, Mack et al. 2017).<br>Disruption of this process may contribute to persistent symptoms and chronic disease activity.<br>However, the factors that impair inflammatory resolution in AD remain poorly understood.<br>Psychological stress is a recognized modifier of AD, associated with worsened pruritus and disease<br>persistence. Experimental incorporation of stress paradigms has improved the translational<br>relevance of AD models (Hall, Cruser et al. 2012). Restraint stress (RS), a model of psychological<br>stress in rodents, activates the hypothalamic-pituitary-adrenal (HPA) axis and may enhance DRG<br>neuronal excitability through glucocorticoid and sympathetic signaling, thereby facilitating A\u03b2<br>fiber\u2013mediated mechanical alloknesis (Buynitsky and Mostofsky 2009). However, prior work has<br>focused largely on stress during active inflammation, emphasizing exacerbation rather than<br>recovery. We hypothesized that psychological stress disrupts the transition to resolution without<br>amplifying peak inflammation, thereby sustaining sensory sensitization during recovery.<\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/06\/0618jc.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of 0618jc.\"><\/object><a id=\"wp-block-file--media-52630983-be45-4d8f-b0b7-4d6255726948\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/06\/0618jc.pdf\">0618jc<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/06\/0618jc.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-52630983-be45-4d8f-b0b7-4d6255726948\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Psychological stress delays inflammatory resolution and promotes sustained sensory sensitization during recovery from atopic dermatitis Qiaofeng Zhao, Alberto Leguina-Ruzzi, Mitsutoshi Tominaga, Yayoi Kamata, Atsuko Kamo, Huiying Wan, Yuping Ran, Kenji Takamori Atopic dermatitis (AD) is a chronic inflammatory disorder characterized by pruritus, eczematouslesions, and epidermal barrier dysfunction, with substantial impact on quality of life (Weidingerand [&hellip;]<\/p>\n","protected":false},"author":24,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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