{"id":3798,"date":"2026-07-31T10:10:47","date_gmt":"2026-07-31T01:10:47","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3798"},"modified":"2026-07-31T10:10:48","modified_gmt":"2026-07-31T01:10:48","slug":"journal-club-26-07-31","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3798","title":{"rendered":"Journal Club 26.07.31"},"content":{"rendered":"\n<p class=\"has-black-color has-text-color has-large-font-size\">From skin to spinal Cord: How IL-17a Drives psoriatic chronic itch<\/p>\n\n\n\n<p class=\"has-medium-font-size\">Xin Liu a,1 , Jian Jiang b,1, Shiying Lin b,1, Wenqiang Ge c, Qingxiao Tao b, Suwen Liu b, Ouyang Zhanmu c, Yang Yang c, Bao Chai d,e, Jingyu Zhang a, Man Li c,*, Hongxiang Chen a,f,**<\/p>\n\n\n\n<h2>Highlights<\/h2>\n\n\n\n<ul>\n<li>\u2022IL-17a directly provokes psoriatic itch by activating IL17ra on sensory neurons.<\/li>\n\n\n\n<li>\u2022Spinal IL-6-astrocyte-IL-1\u03b2 axis acts as a central itch amplifier in psoriasis.<\/li>\n\n\n\n<li>\u2022A novel IL-17a-driven neuro-immune circuit connects skin to spinal cord.<\/li>\n<\/ul>\n\n\n\n<h2>Abstract<\/h2>\n\n\n\n<p>Interleukin-17a (IL-17a) has been established as a master regulator of inflammatory cascades in psoriasis pathogenesis. Monoclonal antibodies targeting IL-17a have demonstrated significant efficacy in relieving psoriasis-related symptoms, including the rapid alleviation of chronic itching. However, whether IL-17a is involved in chronic psoriatic pruritus and the specific mechanisms of its action remain poorly understood. In this study, we demonstrate that IL-17a significantly exacerbates chronic itch in a murine model of psoriasis. Mechanistically, IL-17a upregulation in psoriatic skin tissues activated the IL-17a receptor (IL-17Ra) in sensory neurons, subsequently promoting the expression of IL-6 in dorsal root ganglion (DRG) neurons. This neuron-derived IL-6 is transported via sensory nerve fibers to the spinal dorsal horn (SDH), where it triggers astrocyte activation and subsequent IL-1\u03b2 secretion to potentiates chronic itch signaling in psoriasis. Our findings uncover a neuroimmune circuit in which IL-17a-IL-17Ra signaling on sensory neurons mediates the propagation of pruritic signals from peripheral skin to the central nervous system, with spinal IL-6-astrocyte-IL-1\u03b2 axis serving as an amplifier of psoriatic pruritus.<\/p>\n\n\n\n<h2>Keywords<\/h2>\n\n\n\n<p>Astrocyte;\u00a0Chronic itch;\u00a0IL-17a;\u00a0Psoriasis;\u00a0Sensory neuron;\u00a0Spinal cord<\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/07\/1-s2.0-S088915912500460X-main.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of 1-s2.0-S088915912500460X-main.\"><\/object><a id=\"wp-block-file--media-9fa71c3b-5cde-47ac-b5b7-731a1fab4c0e\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/07\/1-s2.0-S088915912500460X-main.pdf\">1-s2.0-S088915912500460X-main<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/07\/1-s2.0-S088915912500460X-main.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-9fa71c3b-5cde-47ac-b5b7-731a1fab4c0e\">Download<\/a><\/div>\n\n\n\n<div class=\"wp-block-file\"><a id=\"wp-block-file--media-8d89f8c6-c51d-472b-bf9a-c9c26eb146f2\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/07\/1-s2.0-S088915912500460X-mmc1-2.docx\">1-s2.0-S088915912500460X-mmc1-2<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/07\/1-s2.0-S088915912500460X-mmc1-2.docx\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-8d89f8c6-c51d-472b-bf9a-c9c26eb146f2\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>From skin to spinal Cord: How IL-17a Drives psoriatic chronic itch Xin Liu a,1 , Jian Jiang b,1, Shiying Lin b,1, Wenqiang Ge c, Qingxiao Tao b, Suwen Liu b, Ouyang Zhanmu c, Yang Yang c, Bao Chai d,e, Jingyu Zhang a, Man Li c,*, Hongxiang Chen a,f,** Highlights Abstract Interleukin-17a (IL-17a) has been established [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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