{"id":3803,"date":"2026-08-06T23:55:52","date_gmt":"2026-08-06T14:55:52","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3803"},"modified":"2026-08-06T23:58:36","modified_gmt":"2026-08-06T14:58:36","slug":"journal-club-26-08-06","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3803","title":{"rendered":"Journal Club 26.08.06"},"content":{"rendered":"\n<h2>Chi3l1 Knockout Mitigates Chronic Itch and Cutaneous Inflammation in Mice<\/h2>\n\n\n\n<p class=\"has-medium-font-size\">Sam Kahler1, Brigid Betz-Stablein1, Fabian Lee1, Joachim Torrano1, Monika Janda2, Clare Primiero1, H, Peter Soyer1 and Dilki Jayasinghe<\/p>\n\n\n\n<p class=\"has-medium-font-size\">CHI3L1, also known as YKL-40, is a 40- kDa glycoprotein that is overexpressed<br>in patients with atopic dermatitis (AD) and is induced by various proinflammatory<br>cytokines. This protein interacts with multiple receptors (He et al,<br>2013; Lee et al, 2016), and its serum levels corelate with the severity of AD in<br>humans. CHI3L1 regulates T helper type 2 cytokines and modulates IgE release<br>(Curtiss et al, 2023; Lee et al, 2022). Antibody therapy targeting CHI3L1 has<br>been shown to improve skin inflammation in AD in mice (Lee et al, 2022; Yu<br>et al, 2024). CHI3L1 also activates IL- 13Ra2 (Kwak et al, 2019). Although IL-<br>13Ra2 was traditionally considered as a decoy receptor, our studies have<br>revealed its crucial role in AD associated itch, with increased expression<br>observed in patients with AD (Xiao et al, 2021). Despite these findings, the<br>role of CHI3L1 in chronic itch sensation remains largely unexplored. This study<br>aims to elucidate the role of CHI3L1 in itch by investigating its interactions with<br>IL-13Ra2 and IL-31 receptor, which are key itch receptors (Meng et al, 2018). In<br>addition, our study explored the function and the effects of CHI3L1 gene<br>knockout (KO) on itch generation and related signaling pathways.<\/p>\n\n\n\n<div class=\"wp-block-file\"><object class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/08\/showPdf-1.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of showPdf-1.\"><\/object><a id=\"wp-block-file--media-f45a54bc-c401-493a-93c1-7c578d2839a3\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/08\/showPdf-1.pdf\">showPdf-1<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/08\/showPdf-1.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-f45a54bc-c401-493a-93c1-7c578d2839a3\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Chi3l1 Knockout Mitigates Chronic Itch and Cutaneous Inflammation in Mice Sam Kahler1, Brigid Betz-Stablein1, Fabian Lee1, Joachim Torrano1, Monika Janda2, Clare Primiero1, H, Peter Soyer1 and Dilki Jayasinghe CHI3L1, also known as YKL-40, is a 40- kDa glycoprotein that is overexpressedin patients with atopic dermatitis (AD) and is induced by various proinflammatorycytokines. This protein interacts [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3803"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3803"}],"version-history":[{"count":3,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3803\/revisions"}],"predecessor-version":[{"id":3808,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3803\/revisions\/3808"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}