{"id":3871,"date":"2026-11-06T03:28:44","date_gmt":"2026-11-05T18:28:44","guid":{"rendered":"https:\/\/misterx95.myds.me\/wordpress\/?p=3871"},"modified":"2026-11-06T03:28:45","modified_gmt":"2026-11-05T18:28:45","slug":"journal-club-26-11-06","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=3871","title":{"rendered":"Journal club 26.11.06"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-large-font-size\"><strong>Defensins mediate skin inflammation and itch in psoriasis<\/strong>                                                                                                                                                                                                                                                                   <\/h2>\n\n\n\n<h2 class=\"wp-block-heading has-small-font-size\">Sharan Kumar Balaji1, Qin Zheng2, Huasheng Yu3, Joann Truong1, Luchiano Giovanni Benjamin Fernando1, Yining Liu1, Clara Shin3, Wenqin Luo3, Xinzhong Dong4 and<\/h2>\n\n\n\n<h2 class=\"wp-block-heading has-small-font-size\">Xintong Dong1<\/h2>\n\n\n\n<p>Psoriasis is an inflammatory skin condition that features marked upregulation of keratinocyte-derived antimicrobial<br>peptides, particularly !-defensins. Yet, the functions of these peptides in skin inflammation remain<br>unclear. In this study, we used a defensin cluster-knockout mouse to evaluate the potential roles of defensins<br>as neuroimmune modulators in psoriasis. Deletion of the defensin gene cluster (Def conditional knockout) in<br>keratinocytes significantly attenuated imiquimod-induced psoriatic inflammation, with reduced hyperkeratosis,<br>erythema, scaling, and expression of inflammatory cytokines and chemokines. In addition, the Def conditionalknockout<br>mice exhibited reduced neutrophil and IL-17\u2192 TCR&#8221;# T-cell infiltration in the psoriatic skin, indicating<br>a critical role of defensins in amplifying T helper 17 immunity. Behavioral analysis further revealed that<br>the loss of defensins reduced psoriatic itch, and we showed that human !-defensin 2 directly activated smalldiameter<br>Mrgpra3 neurons to elicit robust scratching. Overall, our study revealed that !-defensins play an<br>important role in mediating inflammation and itch associated with psoriasis by activating neutrophils, type 17<br>immune response, and pruriceptive sensory neurons, suggesting defensin signaling as a potential therapeutic<br>target in psoriasis.<\/p>\n\n\n\n<div data-wp-interactive=\"core\/file\" class=\"wp-block-file\"><object data-wp-bind--hidden=\"!state.hasPdfPreview\" hidden class=\"wp-block-file__embed\" data=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/11\/main.pdf\" type=\"application\/pdf\" style=\"width:100%;height:600px\" aria-label=\"Embed of main.\"><\/object><a id=\"wp-block-file--media-b7f06a24-3d67-4d0a-b333-bdcb3af5edfc\" href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/11\/main.pdf\">main<\/a><a href=\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2026\/11\/main.pdf\" class=\"wp-block-file__button wp-element-button\" download aria-describedby=\"wp-block-file--media-b7f06a24-3d67-4d0a-b333-bdcb3af5edfc\">Download<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Defensins mediate skin inflammation and itch in psoriasis Sharan Kumar Balaji1, Qin Zheng2, Huasheng Yu3, Joann Truong1, Luchiano Giovanni Benjamin Fernando1, Yining Liu1, Clara Shin3, Wenqin Luo3, Xinzhong Dong4 and Xintong Dong1 Psoriasis is an inflammatory skin condition that features marked upregulation of keratinocyte-derived antimicrobialpeptides, particularly !-defensins. Yet, the functions of these peptides in skin [&hellip;]<\/p>\n","protected":false},"author":25,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-3871","post","type-post","status-publish","format-standard","hentry","category-jc"],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3871","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/25"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3871"}],"version-history":[{"count":3,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3871\/revisions"}],"predecessor-version":[{"id":3875,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/3871\/revisions\/3875"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}