{"id":5,"date":"2012-07-19T05:37:50","date_gmt":"2012-07-19T05:37:50","guid":{"rendered":"http:\/\/misterx95.myds.me\/wordpress\/?p=5"},"modified":"2012-07-25T14:49:12","modified_gmt":"2012-07-25T05:49:12","slug":"journal-club-2012-07-19","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=5","title":{"rendered":"Journal club 2012-07-19"},"content":{"rendered":"

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\r\n\t\r\n\t\t\"Sci\r\n\t<\/a>\r\n<\/dt>\r\n
\r\n\tFilename<\/strong> : sci-signal-2011-the-distinct-roles-of-two-gpcrs-mrgprc11-and-par2-in-itch-and-hyperalgesia.pdf<\/a> (661 KB)\r\n\t
\r\n\tCaption<\/strong> : \r\n<\/dd>\r\n<\/dl>

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The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia<\/h2>\n

Qin Liu1<\/sup><\/a>*<\/sup>, Hao-Jui Weng1<\/sup><\/a>*<\/sup>, Kush N. Patel1<\/sup><\/a>*<\/sup>, Zongxiang Tang1<\/sup>,2<\/sup>, Haihua Bai1<\/sup>,3<\/sup>, Martin Steinhoff4<\/sup>,5<\/sup>, and Xinzhong Dong1<\/sup>,6<\/sup><\/a>\"{dagger}\"<\/sup><\/p>\n

1<\/sup>\u00a0Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
\n2<\/sup>\u00a0Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210046, China.
\n3<\/sup>\u00a0Inner Mongolia University for the Nationalities, School of Life Science, 22 Huolinhe Street, Tongliao City 028043, China.
\n4<\/sup>\u00a0Department of Dermatology, University of California, San Francisco, CA 94143, USA.
\n5<\/sup>\u00a0Department of Surgery, University of California, San Francisco, CA 94143, USA.
\n6<\/sup>\u00a0Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.<\/p>\n

<\/a>*<\/sup>\u00a0These authors contributed equally to this work.<\/p>\n

 <\/p>\n

Abstract:<\/strong>\u00a0Itch has been defined as an unpleasant skin sensation that triggers the urge to scratch. Primary sensory dorsal root ganglia neurons detect itch stimuli through peripheral axons in the skin, playing an important role in generating itch. Itch is broadly categorized as histaminergic (sensitive to antihistamines) or nonhistaminergic. The peptide Ser-Leu-Ile-Gly-Arg-Leu (SLIGRL) is an itch-inducing agent widely used to study histamine-independent itch. Here, we show that Mrgprs (Mas-related G protein\u2013coupled receptors), particularly MrgprC11, rather than PAR2 (protease-activated receptor 2) as previously thought, mediate this type of itch. A shorter peptide, SLIGR, which specifically activates PAR2 but not MrgprC11, induced thermal pain hypersensitivity in mice but not a scratch response. Therefore, although both Mrgpr and PAR2 are SLIGRL-responsive G protein\u2013coupled receptors present in dorsal root ganglia, each plays a specific role in mediating itch and pain.<\/p>\n","protected":false},"excerpt":{"rendered":"

The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia Qin Liu1*, Hao-Jui Weng1*, Kush N. Patel1*, Zongxiang Tang1,2, Haihua Bai1,3, Martin Steinhoff4,5, and Xinzhong Dong1,6 1\u00a0Solomon H. Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. 2\u00a0Nanjing University […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/5"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5"}],"version-history":[{"count":12,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/5\/revisions"}],"predecessor-version":[{"id":32,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/5\/revisions\/32"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}