\n
BACKGROUND:<\/h4>\n
Recent studies have indicated that Toll-like receptor 4 (TLR4<\/span>), a pathogen-recognition receptor that triggers inflammatory signals in innate immune cells, is also expressed on sensory neurons, implicating its putative role in sensory signal transmission. However, the possible function of sensory neuron\u00a0TLR4<\/span>\u00a0has not yet been formally addressed. In this regard, we investigated the role of\u00a0TLR4<\/span>\u00a0in itch signal transmission.<\/p>\nRESULTS:<\/h4>\n
TLR4<\/span>\u00a0was expressed on a subpopulation of dorsal root ganglia (DRG) sensory neurons that express\u00a0TRPV1<\/span>. In\u00a0TLR4<\/span>-knockout mice, histamine-induced itch responses were compromised while\u00a0TLR4<\/span>\u00a0activation by LPS did not directly elicit an itch response. Histamine-induced intracellular calcium signals and inward currents were comparably reduced in\u00a0TLR4<\/span>-deficient sensory neurons. Reduced histamine sensitivity in theTLR4<\/span>-deficient neurons was accompanied by a decrease in\u00a0TRPV1<\/span>\u00a0activity<\/span>. Heterologous expression experiments in HEK293T cells indicated thatTLR4<\/span>\u00a0expression enhanced capsaicin-induced intracellular calcium signals and inward currents.<\/p>\nCONCLUSIONS:<\/h4>\n
Our data show that\u00a0TLR4<\/span>\u00a0on sensory neurons\u00a0enhances<\/span>\u00a0histamine-induced itch signal transduction by\u00a0potentiating<\/span>\u00a0TRPV1<\/span>\u00a0activity<\/span>. The results suggest that\u00a0TLR4<\/span>\u00a0could be a novel target for the treatment of enhanced itch sensation.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":" TLR4\u00a0enhances\u00a0histamine-mediated\u00a0pruritus\u00a0by\u00a0potentiating\u00a0TRPV1\u00a0activity. Min H,\u00a0Lee H,\u00a0Lim H,\u00a0Jang YH,\u00a0Chung SJ,\u00a0Lee CJ,\u00a0Lee SJ1. Author information Abstract BACKGROUND: Recent studies have indicated that Toll-like receptor 4 (TLR4), a pathogen-recognition receptor that triggers inflammatory signals in innate immune cells, is also expressed on sensory neurons, implicating its putative role in sensory signal transmission. However, the possible function of sensory neuron\u00a0TLR4\u00a0has […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/868"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=868"}],"version-history":[{"count":3,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/868\/revisions"}],"predecessor-version":[{"id":872,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/868\/revisions\/872"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=868"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=868"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=868"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
![\"TLR4](\"https:\/\/misterx95.myds.me\/wordpress\/wp-content\/plugins\/eg-attachments\/img\/flags\/document.png\")
\r\n\t<\/a>\r\n<\/dt>\r\n