{"id":915,"date":"2014-12-29T12:08:00","date_gmt":"2014-12-29T03:08:00","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=915"},"modified":"2014-12-29T12:08:00","modified_gmt":"2014-12-29T03:08:00","slug":"journal-club-2014-12-29","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=915","title":{"rendered":"Journal Club 2014.12.29"},"content":{"rendered":"
\r\n
\r\n\t\r\n\t\t\"TRPA1\r\n\t<\/a>\r\n<\/dt>\r\n
\r\n\tFilename<\/strong> : trpa1-chanels-mediate-acute-neurogenic-inflammation-and-pain-produced-by-bacterial-endotoxins.pdf<\/a> (2 MB)\r\n\t
\r\n\tCaption<\/strong> : \r\n<\/dd>\r\n<\/dl>

<\/p><\/div>\n

TRPA1 channels mediate acute neurogenic
\ninflammation and pain produced by bacterial
\nendotoxins
\nVictor Meseguer1
\n, Yeranddy A. Alpizar2, Enoch Luis1
\n, Sendoa Tajada3, Bristol Denlinger1
\n, Otto Fajardo1
\n,Jan-Albert Manenschijn1
\n, Carlos Ferna\u00b4ndez-Pen\u02dca1
\n, Arturo Talavera2,4, Tatiana Kichko5, Bele\u00b4n Navia6,
\nAlicia Sa\u00b4nchez2, Rosa Sen\u02dcar\u0131\u00b4s6, Peter Reeh5, Mar\u0131\u00b4a Teresa Pe\u00b4rez-Garc\u0131\u00b4a3, Jose\u00b4 Ramo\u00b4n Lo\u00b4pez-Lo\u00b4pez3,
\nThomas Voets2, Carlos Belmonte1
\n, Karel Talavera1,2,* & Fe\u00b4lix Viana1,*<\/p>\n

Gram-negative bacterial infections are accompanied by inflammation and somatic or
\nvisceral pain. These symptoms are generally attributed to sensitization of nociceptors
\nby inflammatory mediators released by immune cells. Nociceptor sensitization during
\ninflammation occurs through activation of the Toll-like receptor 4 (TLR4) signalling pathway
\nby lipopolysaccharide (LPS), a toxic by-product of bacterial lysis. Here we show that LPS
\nexerts fast, membrane delimited, excitatory actions via TRPA1, a transient receptor potential
\ncation channel that is critical for transducing environmental irritant stimuli into nociceptor
\nactivity. Moreover, we find that pain and acute vascular reactions, including neurogenic
\ninflammation (CGRP release) caused by LPS are primarily dependent on TRPA1 channel
\nactivation in nociceptive sensory neurons, and develop independently of TLR4 activation. The
\nidentification of TRPA1 as a molecular determinant of direct LPS effects on nociceptors offers
\nnew insights into the pathogenesis of pain and neurovascular responses during bacterial
\ninfections and opens novel avenues for their treatment.<\/p>\n","protected":false},"excerpt":{"rendered":"

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins Victor Meseguer1 , Yeranddy A. Alpizar2, Enoch Luis1 , Sendoa Tajada3, Bristol Denlinger1 , Otto Fajardo1 ,Jan-Albert Manenschijn1 , Carlos Ferna\u00b4ndez-Pen\u02dca1 , Arturo Talavera2,4, Tatiana Kichko5, Bele\u00b4n Navia6, Alicia Sa\u00b4nchez2, Rosa Sen\u02dcar\u0131\u00b4s6, Peter Reeh5, Mar\u0131\u00b4a Teresa Pe\u00b4rez-Garc\u0131\u00b4a3, Jose\u00b4 Ramo\u00b4n Lo\u00b4pez-Lo\u00b4pez3, Thomas Voets2, Carlos […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/915"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=915"}],"version-history":[{"count":1,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/915\/revisions"}],"predecessor-version":[{"id":917,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/915\/revisions\/917"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=915"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=915"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=915"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}