{"id":958,"date":"2015-03-20T10:11:39","date_gmt":"2015-03-20T01:11:39","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=958"},"modified":"2015-03-20T10:11:40","modified_gmt":"2015-03-20T01:11:40","slug":"journal-club-2015-3-20","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=958","title":{"rendered":"Journal club 2015.3.20"},"content":{"rendered":"

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\r\n\t\r\n\t\t\"Akiyama\r\n\t<\/a>\r\n<\/dt>\r\n
\r\n\tFilename<\/strong> : akiyama-et-al_2015_nalfurafine-suppresses-pruritogen-and-touch-evoked-scratching-behavior-in.pdf<\/a> (489 KB)\r\n\t
\r\n\tCaption<\/strong> : \r\n<\/dd>\r\n<\/dl>

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Nalfurafine<\/span> suppresses<\/span> pruritogen<\/span>– and touch-evoked<\/span> scratching<\/span> behavior<\/span> in models<\/span> of acute<\/span> and chronic<\/span> itch<\/span>in mice<\/span>.<\/h1>\n
Akiyama T<\/a>1<\/sup>, Carstens MI<\/a>, Piecha D<\/a>, Steppan S<\/a>, Carstens E<\/a>.<\/div>\n
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Author information<\/span><\/a><\/h3>\n
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Abstract<\/h3>\n
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The kappa-opioid agonist, nalfurafine<\/span>, has been approved in Japan for treatment of itch<\/span> in patients with chronic<\/span> kidney disease. We presently investigated if systemic administration of nalfurafine<\/span> inhibited ongoing or touch-evoked<\/span> scratching<\/span> behavior<\/span> (alloknesis) following acute<\/span>intradermal injection of histamine or the non-histaminergic itch<\/span> mediator, chloroquine, in mice<\/span>. We also investigated if nalfurafine<\/span> suppressed spontaneous or touch-evoked<\/span> scratching<\/span> in an experimental model of chronic<\/span> dry skin itch<\/span>. Nalfurafine<\/span> reduced scratching<\/span> evoked by histamine and chloroquine. Following acute<\/span> histamine, but not chloroquine, low-threshold mechanical stimuli reliably elicited directed hindlimb scratching<\/span>behavior<\/span>, which was significantly attenuated by nalfurafine<\/span>. In mice<\/span> with experimental dry skin, nalfurafine<\/span> abolished spontaneous scratching<\/span> but had no effect on alloknesis. Nalfurafine<\/span> thus appears to be a promising treatment for acute<\/span> itch<\/span> as well as ongoing itch<\/span> of dry skin.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Nalfurafine suppresses pruritogen– and touch-evoked scratching behavior in models of acute and chronic itchin mice. Akiyama T1, Carstens MI, Piecha D, Steppan S, Carstens E. Author information Abstract The kappa-opioid agonist, nalfurafine, has been approved in Japan for treatment of itch in patients with chronic kidney disease. We presently investigated if systemic administration of nalfurafine […]<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/958"}],"collection":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=958"}],"version-history":[{"count":2,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/958\/revisions"}],"predecessor-version":[{"id":961,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=\/wp\/v2\/posts\/958\/revisions\/961"}],"wp:attachment":[{"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=958"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=958"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/misterx95.myds.me\/wordpress\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=958"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}