{"id":965,"date":"2015-03-27T10:24:48","date_gmt":"2015-03-27T01:24:48","guid":{"rendered":"http:\/\/misterx95.myds.me\/?p=965"},"modified":"2015-03-27T10:24:48","modified_gmt":"2015-03-27T01:24:48","slug":"journal-clb-27-3-2015","status":"publish","type":"post","link":"https:\/\/misterx95.myds.me\/wordpress\/?p=965","title":{"rendered":"journal clb 27-3-2015"},"content":{"rendered":"<h1 id=\"tit0005\" class=\"svTitle\">Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC\/Nga murine model of atopic dermatitis<\/h1>\n<ul class=\"authorGroup noCollab svAuthor\">\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b0eec0\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Bo-Kyung Park<\/span><\/a><a id=\"baff0005\" class=\"intra_ref auth_aff\" title=\"Affiliation: a\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0005\"><sup><span style=\"color: #0066cc;font-size: small\">a<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b0ef74\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Yang-Chun Park<\/span><\/a><a id=\"baff0010\" class=\"intra_ref auth_aff\" title=\"Affiliation: b\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0010\"><sup><span style=\"color: #0066cc;font-size: small\">b<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b0f028\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">In Chul Jung<\/span><\/a><a id=\"baff0015\" class=\"intra_ref auth_aff\" title=\"Affiliation: c\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0015\"><sup><span style=\"color: #0066cc;font-size: small\">c<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b0f0dc\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Seung-Hyung Kim<\/span><\/a><a id=\"baff0020\" class=\"intra_ref auth_aff\" title=\"Affiliation: d\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0020\"><sup><span style=\"color: #0066cc;font-size: small\">d<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b19a50\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Jeong June Choi<\/span><\/a><a id=\"baff0020\" class=\"intra_ref auth_aff\" title=\"Affiliation: d\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0020\"><sup><span style=\"color: #0066cc;font-size: small\">d<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b19b04\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Moonho Do<\/span><\/a><a id=\"baff0025\" class=\"intra_ref auth_aff\" title=\"Affiliation: e\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0025\"><sup><span style=\"color: #0066cc;font-size: small\">e<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b19bb8\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Sun Yeou Kim<\/span><\/a><a id=\"baff0025\" class=\"intra_ref auth_aff\" title=\"Affiliation: e\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0025\"><sup><span style=\"color: #0066cc;font-size: small\">e<\/span><\/sup><\/a>,<\/li>\n<li class=\"smh5\"><a id=\"authname_N49e6a6e0N32b19c6c\" class=\"authorName svAuthor\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#\"><span style=\"color: #0066cc\">Mirim Jin<\/span><\/a><a id=\"baff0005\" class=\"intra_ref auth_aff\" title=\"Affiliation: a\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#aff0005\"><sup><span style=\"color: #0066cc;font-size: small\">a<\/span><\/sup><\/a><sup><span style=\"font-size: small\">, <\/span><\/sup><a id=\"bcor1\" class=\"intra_ref auth_corr\" title=\"Corresponding author contact information\" href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S0378874115001191#cor1\"><\/a><sup><span style=\"font-size: small\">, <\/span><\/sup><\/li>\n<\/ul>\n<h2 id=\"authorab00051\" class=\"secHeading\">Abstract<\/h2>\n<h4 id=\"absSec_1\">Ethnopharmacological relevance<\/h4>\n<p id=\"sp0050\">Gamisasangja-tang (GST) is a traditional herbal formula prescribed for patients with intractable pruritus in association with various inflammatory skin diseases. To evaluate the effects of GST on pruritic skin inflammation and investigate its cellular and molecular mechanisms.<\/p>\n<h4 id=\"absSec_2\">Materials and methods<\/h4>\n<p id=\"sp0060\">We orally administered GST to NC\/Nga (NC) mice, an animal model of atopic dermatitis. Scratching frequency and the dermatitis index were evaluated, and histological examination was performed using hematoxylin and eosin and toluidine blue staining. The levels of interleukin (IL)-31 and T-helper cell type 2 (T<sub><span style=\"font-size: small\">H<\/span><\/sub>2) cytokines were determined in both the dorsal skin and cultured splenocytes by real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. The serum levels of chemokines and immunoglobulin E (IgE) were determined by ELISA. Changes in the inflammatory cell population were analyzed by a hemocytometer.<\/p>\n<h4 id=\"absSec_3\">Results<\/h4>\n<p id=\"sp0065\">GST significantly lowered scratching frequency and inhibited increases in dermatitis index, thickness of epidermis\/dermis and infiltration of chemokine (C-C motif) receptor 3 (CCR3)<sup><span style=\"font-size: small\">+<\/span><\/sup> and cluster of differentiation (CD)117<sup><span style=\"font-size: small\">+<\/span><\/sup>\/Fc\u03b5RI<em>\u03b1<\/em> (Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide)<sup><span style=\"font-size: small\">+<\/span><\/sup> cells in atopic skin. Both <em>IL-<\/em>31 mRNA expression and production were significantly reduced by GST, which was accomrease in the levels of <em>IL-4<\/em>, <em>IL-5<\/em>, and <em>IL-13<\/em>. Further, GST treatment suppressed the secretion of eotaxin, TARC (thymus and activation-regulated chemokine), IgE, and increases in the number of basophils and eosinophils in the blood.<\/p>\n<h4 id=\"absSec_4\">Conclusion<\/h4>\n<p id=\"sp0070\">GST may have potential as an effective treatment for pruritic skin disease such as atopic dermatitis<\/p>\n<p><a href=\"http:\/\/misterx95.myds.me\/wordpress\/wp-content\/uploads\/2015\/03\/gamisasangja-tang.pdf\">gamisasangja tang<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC\/Nga murine model of atopic dermatitis Bo-Kyung Parka, Yang-Chun Parkb, In Chul Jungc, Seung-Hyung Kimd, Jeong June Choid, Moonho Doe, Sun Yeou Kime, Mirim Jina, , Abstract Ethnopharmacological relevance Gamisasangja-tang (GST) is a traditional herbal formula prescribed for patients with intractable pruritus in association with various [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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