Mast Cells Initiate Type 2 Inflammation through Tryptase Released by MRGPRX2/MRGPRB2 Activation in Atopic Dermatitis

https://doi.org/10.1016/j.jid.2023.06.201

Tao Jia ¹³, Delu Che ¹²³, Yi Zheng ¹, Huan Zhang ¹, Yaxiang Li ¹, Tong Zhou ¹, Bin Peng ¹, Xueshan Du ¹, Longfei Zhu ¹, Jingang An ¹, Songmei Geng ¹

¹Department of Dermatology, Northwest Hospital, The Second Hospital Affiliated to Xi’an Jiaotong University, Xi’an, China

²Center for Dermatology Disease, Precision Medical Institute, Xi’an, China

Keywords

AD: Atopic Dermatitis, ADI: Atopic Dermatitis Index, MC: Mast Cell, TSLP: Thymic Stromal Lymphopoietin