Dr. Wook-Joo Lee
FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice.
In Kim H, Lee GB, Song DE, Sanjel B, Lee WJ, Shim WS.Life Sci. 2023 Jul 15;325:121786. doi: 10.1016/j.lfs.2023.121786. Epub 2023 May 16.PMID: 37201698. PMID: 36632132
Rg3-enriched Korean red ginseng alleviates chloroquine-induced itch and dry skin pruritus in an MrgprA3-dependent manner in mice.
Lee WJ, Shim WS.Integr Med Res. 2023 Mar;12(1):100916. doi: 10.1016/j.imr.2022.100916. Epub 2022 Dec 23.PMID: 36632132
Cutaneous Neuroimmune Interactions of TSLP and TRPV4 Play Pivotal Roles in Dry Skin-Induced Pruritus.
Lee WJ, Shim WS.Front Immunol. 2021 Dec 2;12:772941. doi: 10.3389/fimmu.2021.772941. eCollection 2021.PMID: 34925342
Crotamiton, an Anti-Scabies Agent, Suppresses Histamine- and Chloroquine-Induced Itch Pathways in Sensory Neurons and Alleviates Scratching in Mice.
Choi DS, Ji Y, Jang Y, Lee WJ, Shim WS.Biomol Ther (Seoul). 2020 Nov 1;28(6):569-575. doi: 10.4062/biomolther.2020.063.PMID: 32536619
Extracts of the leaves of Pyrus ussuriensis Maxim. Alleviate itch sensation via TSLP-dependent manner in mouse models of atopic dermatitis.
Kim BH, Lee WJ, Sanjel B, Cho K, Son YK, Park HY, Kim SY, Shim WS.Physiol Behav. 2019 Oct 15;210:112624. doi: 10.1016/j.physbeh.2019.112624. Epub 2019 Jul 17.PMID: 3132551
Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of MrgprA3/TRPA1-mediated pathway.
Lee WJ, Kim YS, Shim WS.J Ginseng Res. 2018 Oct;42(4):470-475. doi: 10.1016/j.jgr.2017.05.004. Epub 2017 May 18.PMID: 30337807
Different perception levels of histamine-induced itch sensation in young adult mice.
Ji Y, Jang Y, Lee WJ, Yang YD, Shim WS.Physiol Behav. 2018 May 1;188:188-193. doi: 10.1016/j.physbeh.2018.02.015. Epub 2018 Feb 9.PMID: 29432788
A novel synthetic Piper amide derivative NED-180 inhibits hyperpigmentation by activating the PI3K and ERK pathways and by regulating Ca2+ influx via TRPM1 channels.
Hwang E, Lee TH, Lee WJ, Shim WS, Yeo EJ, Kim S, Kim SY.Pigment Cell Melanoma Res. 2016 Jan;29(1):81-91. doi: 10.1111/pcmr.12430.PMID: 26459162
Red ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons.
Jang Y, Lee WJ, Hong GS, Shim WS.J Ginseng Res. 2015 Jul;39(3):257-64. doi: 10.1016/j.jgr.2015.01.004. Epub 2015 Jan 22.PMID: 26199558
Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway.
Maeng HJ, Lee WJ, Jin QR, Chang JE, Shim WS.Eur J Pharm Sci. 2014 Oct 1;62:189-96. doi: 10.1016/j.ejps.2014.05.023. Epub 2014 Jun 5.PMID: 24909729
Dr. Sanjel Babina
FSLLRY-NH2, a protease-activated receptor 2 (PAR2) antagonist, activates mas-related G protein-coupled receptor C11 (MrgprC11) to induce scratching behaviors in mice.
In Kim H, Lee GB, Song DE, Sanjel B, Lee WJ, Shim WS.Life Sci. 2023 Jul 15;325:121786. doi: 10.1016/j.lfs.2023.121786. Epub 2023 May 16.PMID: 37201698
The contribution of mouse models to understanding atopic dermatitis.
Sanjel B, Shim WS.Biochem Pharmacol. 2022 Sep;203:115177. doi: 10.1016/j.bcp.2022.115177. Epub 2022 Jul 14.PMID: 35843300 Review. PMID: 34766332
Glucosylsphingosine evokes pruritus via activation of 5-HT2A receptor and TRPV4 in sensory neurons.
Sanjel B, Kim BH, Song MH, Carstens E, Shim WS.Br J Pharmacol. 2022 May;179(10):2193-2207. doi: 10.1111/bph.15733. Epub 2022 Feb 4.PMID: 34766332
Recent advances in understanding the molecular mechanisms of cholestatic pruritus: A review.
Sanjel B, Shim WS.Biochim Biophys Acta Mol Basis Dis. 2020 Dec 1;1866(12):165958. doi: 10.1016/j.bbadis.2020.165958. Epub 2020 Sep 5.PMID: 32896605 Free article. Review. PMID: 31350433
BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus.
Sanjel B, Maeng HJ, Shim WS.Sci Rep. 2019 Jul 26;9(1):10888. doi: 10.1038/s41598-019-47267-5.PMID: 31350433