List of Publications (2011-Current)
2023
Kim, Jin-Cheol; Shim, Won-Sik; Kwak, In-Suk; Lee, Dong-Hun; Park, Jin-Seo; Lee, So-Yeon; Kang, Seok-Young; Chung, Bo-Young; Park, Chun-Wook; Kim, Hye-One
Pathogenesis and Treatment of Pruritus Associated with Chronic Kidney Disease and Cholestasis Journal Article
In: IJMS, vol. 24, no. 2, 2023, ISSN: 1422-0067.
Abstract | Links | BibTeX | Tags: Cholestasis, Chronic kidney disease, Itch
@article{Kim2023,
title = {Pathogenesis and Treatment of Pruritus Associated with Chronic Kidney Disease and Cholestasis},
author = {Jin-Cheol Kim and Won-Sik Shim and In-Suk Kwak and Dong-Hun Lee and Jin-Seo Park and So-Yeon Lee and Seok-Young Kang and Bo-Young Chung and Chun-Wook Park and Hye-One Kim},
doi = {10.3390/ijms24021559},
issn = {1422-0067},
year = {2023},
date = {2023-01-00},
urldate = {2023-01-00},
journal = {IJMS},
volume = {24},
number = {2},
publisher = {MDPI AG},
abstract = {Itching is an unpleasant sensation that provokes the desire to scratch. In general, itching is caused by dermatologic diseases, but it can also be caused by systemic diseases. Since itching hampers patients’ quality of life, it is important to understand the appropriate treatment and pathophysiology of pruritus caused by systemic diseases to improve the quality of life. Mechanisms are being studied through animal or human studies, and various treatments are being tested through clinical trials. We report current trends of two major systemic diseases: chronic kidney disease and cholestatic liver disease. This review summarizes the causes and pathophysiology of systemic diseases with pruritus and appropriate treatments. This article will contribute to patients’ quality of life. Further research will help understand the mechanisms and develop new strategies in the future.},
keywords = {Cholestasis, Chronic kidney disease, Itch},
pubstate = {published},
tppubtype = {article}
}
Itching is an unpleasant sensation that provokes the desire to scratch. In general, itching is caused by dermatologic diseases, but it can also be caused by systemic diseases. Since itching hampers patients’ quality of life, it is important to understand the appropriate treatment and pathophysiology of pruritus caused by systemic diseases to improve the quality of life. Mechanisms are being studied through animal or human studies, and various treatments are being tested through clinical trials. We report current trends of two major systemic diseases: chronic kidney disease and cholestatic liver disease. This review summarizes the causes and pathophysiology of systemic diseases with pruritus and appropriate treatments. This article will contribute to patients’ quality of life. Further research will help understand the mechanisms and develop new strategies in the future.
2020
Sanjel, Babina; Shim, Won-Sik
Recent advances in understanding the molecular mechanisms of cholestatic pruritus: A review Journal Article
In: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol. 1866, no. 12, 2020, ISSN: 0925-4439.
Abstract | Links | BibTeX | Tags: Animal model, Cholestasis, Itch
@article{Sanjel2020,
title = {Recent advances in understanding the molecular mechanisms of cholestatic pruritus: A review},
author = {Babina Sanjel and Won-Sik Shim},
doi = {10.1016/j.bbadis.2020.165958},
issn = {0925-4439},
year = {2020},
date = {2020-12-00},
urldate = {2020-12-00},
journal = {Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease},
volume = {1866},
number = {12},
publisher = {Elsevier BV},
abstract = {Cholestasis, a condition characterized by an abnormal decrease in bile flow, is accompanied by various symptoms such as pruritus. Although cholestatic pruritus is a prominent condition, its precise mechanisms have largely been elusive. Recently, advancements have been made for understanding the etiology and pathogenesis of cholestatic pruritus. The current review therefore focuses on summarizing the overall progress made in the elucidation of its molecular mechanisms. We have reviewed the available animal models on cholestasis to compare the differences between them, characterized potential pruritogens involved in cholestatic pruritus, and have summarized the receptor and ion channels implicated in the condition. Finally, we have discussed the available treatment options for alleviation of cholestatic pruritus. As our understanding of the mechanisms of cholestatic pruritus deepens, novel strategies to cure this condition are awaited.},
keywords = {Animal model, Cholestasis, Itch},
pubstate = {published},
tppubtype = {article}
}
Cholestasis, a condition characterized by an abnormal decrease in bile flow, is accompanied by various symptoms such as pruritus. Although cholestatic pruritus is a prominent condition, its precise mechanisms have largely been elusive. Recently, advancements have been made for understanding the etiology and pathogenesis of cholestatic pruritus. The current review therefore focuses on summarizing the overall progress made in the elucidation of its molecular mechanisms. We have reviewed the available animal models on cholestasis to compare the differences between them, characterized potential pruritogens involved in cholestatic pruritus, and have summarized the receptor and ion channels implicated in the condition. Finally, we have discussed the available treatment options for alleviation of cholestatic pruritus. As our understanding of the mechanisms of cholestatic pruritus deepens, novel strategies to cure this condition are awaited.
2019
Sanjel, Babina; Maeng, Han-Joo; Shim, Won-Sik
BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus Journal Article
In: Sci Rep, vol. 9, no. 1, 2019, ISSN: 2045-2322.
Abstract | Links | BibTeX | Tags: Animal model, Calcium imaging, Cholestasis, Dorsal root ganglia, MrgprC11, MRGPRX1, Scratching behavior
@article{Sanjel2019,
title = {BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus},
author = {Babina Sanjel and Han-Joo Maeng and Won-Sik Shim},
doi = {10.1038/s41598-019-47267-5},
issn = {2045-2322},
year = {2019},
date = {2019-12-00},
urldate = {2019-12-00},
journal = {Sci Rep},
volume = {9},
number = {1},
publisher = {Springer Science and Business Media LLC},
abstract = {Pruritus is an unexpected symptom observed in cholestasis and its mechanism is still unclear. Here, we show that bovine adrenal medulla (BAM) 8–22, an endogenous itch-inducing peptide, could be involved in cholestatic pruritus. It was found that bile duct ligation (BDL) mice, an obstructive cholestasis model, showed increased spontaneous scratching behaviour. Importantly, the mRNA level of proenkephalin, a precursor polypeptide of BAM8-22, was significantly increased in the skin of BDL mice. Furthermore, the mRNA level of Mrgprx1, which encodes a receptor for BAM8-22, was significantly increased in the dorsal root ganglia (DRG) of BDL mice. This was further confirmed by elevation of intracellular calcium levels upon BAM8-22 treatment in primarily-cultured DRG neurons. In addition, BDL mice showed augmented scratching behaviour by BAM8-22, indicating enhanced activity of MRGPRX1. Moreover, the skin homogenate of BDL mice induced elevation of intracellular calcium levels through MRGPRX1. Finally, among the various bile acids, chenodeoxycholic acid significantly increased proenkephalin transcription in a human keratinocyte cell line (HaCaT). In conclusion, cholestatic pruritus could be attributed in part to enhanced action of both BAM8-22 in the skin and its receptor MRGPRX1 in sensory neurons.},
keywords = {Animal model, Calcium imaging, Cholestasis, Dorsal root ganglia, MrgprC11, MRGPRX1, Scratching behavior},
pubstate = {published},
tppubtype = {article}
}
Pruritus is an unexpected symptom observed in cholestasis and its mechanism is still unclear. Here, we show that bovine adrenal medulla (BAM) 8–22, an endogenous itch-inducing peptide, could be involved in cholestatic pruritus. It was found that bile duct ligation (BDL) mice, an obstructive cholestasis model, showed increased spontaneous scratching behaviour. Importantly, the mRNA level of proenkephalin, a precursor polypeptide of BAM8-22, was significantly increased in the skin of BDL mice. Furthermore, the mRNA level of Mrgprx1, which encodes a receptor for BAM8-22, was significantly increased in the dorsal root ganglia (DRG) of BDL mice. This was further confirmed by elevation of intracellular calcium levels upon BAM8-22 treatment in primarily-cultured DRG neurons. In addition, BDL mice showed augmented scratching behaviour by BAM8-22, indicating enhanced activity of MRGPRX1. Moreover, the skin homogenate of BDL mice induced elevation of intracellular calcium levels through MRGPRX1. Finally, among the various bile acids, chenodeoxycholic acid significantly increased proenkephalin transcription in a human keratinocyte cell line (HaCaT). In conclusion, cholestatic pruritus could be attributed in part to enhanced action of both BAM8-22 in the skin and its receptor MRGPRX1 in sensory neurons.