List of Publications (2011-Current)
2024
Kim, Ji Young Um Han Bi Kim Won‐Sik Shim Wook Joo Lee So Yeon Lee Jin Seo Park Jin Cheol Kim In Suk Kwak Bo Young Chung Chun Wook Park Hye One
In: Clin Experimental Allergy, vol. 54, no. 2, pp. 152–155, 2024, ISSN: 1365-2222.
Links | BibTeX | Tags: Itch, Keratinocytes, TRPV3, TSLP
@article{Um2023,
title = {The transient receptor potential vanilloid‐3 (TRPV3) channel in epidermal keratinocytes induce thymic interstitial lymphopoietin: Implications for TRPV3‐mediated itch pathways},
author = {Ji Young Um
Han Bi Kim
Won‐Sik Shim
Wook Joo Lee
So Yeon Lee
Jin Seo Park
Jin Cheol Kim
In Suk Kwak
Bo Young Chung
Chun Wook Park
Hye One Kim},
doi = {10.1111/cea.14426},
issn = {1365-2222},
year = {2024},
date = {2024-02-00},
urldate = {2024-02-00},
journal = {Clin Experimental Allergy},
volume = {54},
number = {2},
pages = {152--155},
publisher = {Wiley},
keywords = {Itch, Keratinocytes, TRPV3, TSLP},
pubstate = {published},
tppubtype = {article}
}
2021
Kim, J; Kim, H; Shim, W; Kwak, I; Chung, B; Kang, S; Park, C; Kim, H
Activation of Transient Receptor Potential Vanilloid-3 Channels in Keratinocytes Induces Pruritus in Humans Journal Article
In: Acta Derm Venereol, vol. 101, no. 8, 2021, ISSN: 1651-2057.
Abstract | Links | BibTeX | Tags: Itch, TRPV3, TSLP
@article{Kim2021,
title = {Activation of Transient Receptor Potential Vanilloid-3 Channels in Keratinocytes Induces Pruritus in Humans},
author = {J Kim and H Kim and W Shim and I Kwak and B Chung and S Kang and C Park and H Kim},
doi = {10.2340/00015555-3855},
issn = {1651-2057},
year = {2021},
date = {2021-08-00},
urldate = {2021-08-00},
journal = {Acta Derm Venereol},
volume = {101},
number = {8},
publisher = {Medical Journals Sweden AB},
abstract = {Carvacrol, a natural transient receptor potential vanilloid-3 activator, has been reported to cause pruritus in mice. This study aimed to evaluate the effects of carvacrol and various antipruritic agents in humans. A stimulation test with carvacrol, β-alanine, and histamine was performed. After application of the pruritic solutions, the skin was stimulated with pinpricks. In inhibition test A, Forsythia suspensa extract, containing forsythoside B (a transient receptor potential vanilloid-3 inhibitor), was applied by pricking prior to stimulation with pruritogens. In inhibition test B, olopatadine solution, tacrolimus ointment, and Scutellaria baicalensis root extract were applied, and carvacrol was applied to the same region. Carvacrol induces moderate pruritus in humans. The pruritus was relieved by Forsythia suspensa extract and olopatadine solution after 20 min of application and by tacrolimus ointment and Scutellaria baicalenis extract after 24 h of application. These results suggest that carvacrol is a pruritogen in humans, and that carvacrol-induced pruritus is inhibited by various antipruritic agents.},
keywords = {Itch, TRPV3, TSLP},
pubstate = {published},
tppubtype = {article}
}
Carvacrol, a natural transient receptor potential vanilloid-3 activator, has been reported to cause pruritus in mice. This study aimed to evaluate the effects of carvacrol and various antipruritic agents in humans. A stimulation test with carvacrol, β-alanine, and histamine was performed. After application of the pruritic solutions, the skin was stimulated with pinpricks. In inhibition test A, Forsythia suspensa extract, containing forsythoside B (a transient receptor potential vanilloid-3 inhibitor), was applied by pricking prior to stimulation with pruritogens. In inhibition test B, olopatadine solution, tacrolimus ointment, and Scutellaria baicalensis root extract were applied, and carvacrol was applied to the same region. Carvacrol induces moderate pruritus in humans. The pruritus was relieved by Forsythia suspensa extract and olopatadine solution after 20 min of application and by tacrolimus ointment and Scutellaria baicalenis extract after 24 h of application. These results suggest that carvacrol is a pruritogen in humans, and that carvacrol-induced pruritus is inhibited by various antipruritic agents.