List of Publications (2011-Current)
2026
Sanjel, Babina; Shim, Won-Sik
TRP channels for itch Book Chapter
In: Dong, Xinzhong; Kim, Brian S.; Follansbee, Taylor (Ed.): The Itch Spectrum, Chapter 4 - TRP channels for itch, pp. 33-43, Academic Press, 2026, ISBN: 978-0-443-34172-4.
Abstract | Links | BibTeX | Tags: Itch, Sensory neuron, Skin, TRP
@inbook{SANJEL202633,
title = {TRP channels for itch},
author = {Babina Sanjel and Won-Sik Shim},
editor = {Xinzhong Dong and Brian S. Kim and Taylor Follansbee},
url = {https://www.sciencedirect.com/science/article/pii/B9780443341724000057},
doi = {https://doi.org/10.1016/B978-0-443-34172-4.00005-7},
isbn = {978-0-443-34172-4},
year = {2026},
date = {2026-01-01},
urldate = {2026-01-01},
booktitle = {The Itch Spectrum},
pages = {33-43},
publisher = {Academic Press},
chapter = {4 - TRP channels for itch},
abstract = {Ion channels are transmembrane proteins that regulate ion flow, essential for rapid signal transduction and nerve excitation. By creating ionic flow across cell membranes, they enable the conversion of various sensations into electrical signals. Itch (pruritus), the sensation that prompts the urge to scratch, also depends on ion channel activity, particularly transient receptor potential (TRP) channels. The most extensively studied TRP channels in itch transmission include TRPV1, TRPA1, and TRPV4. These channels, primarily located in peripheral sensory nerves and skin keratinocytes, play a critical role in transmitting both histamine- and nonhistamine-dependent itch signals. This chapter explores the role of these TRP channels in itch sensation, examining how they contribute to the signaling pathways involved in itch. In addition, potential therapeutic strategies targeting TRP channels for itch-related conditions and the associated limitations are discussed.},
keywords = {Itch, Sensory neuron, Skin, TRP},
pubstate = {published},
tppubtype = {inbook}
}
Ion channels are transmembrane proteins that regulate ion flow, essential for rapid signal transduction and nerve excitation. By creating ionic flow across cell membranes, they enable the conversion of various sensations into electrical signals. Itch (pruritus), the sensation that prompts the urge to scratch, also depends on ion channel activity, particularly transient receptor potential (TRP) channels. The most extensively studied TRP channels in itch transmission include TRPV1, TRPA1, and TRPV4. These channels, primarily located in peripheral sensory nerves and skin keratinocytes, play a critical role in transmitting both histamine- and nonhistamine-dependent itch signals. This chapter explores the role of these TRP channels in itch sensation, examining how they contribute to the signaling pathways involved in itch. In addition, potential therapeutic strategies targeting TRP channels for itch-related conditions and the associated limitations are discussed.