The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves.
Abstract
BACKGROUND:
Pruritus is a cardinal symptom of atopic dermatitis, and an increased cutaneous sensory network is thought to contribute to pruritus. Although the immune cell-IL-31-neuron axis has been implicated in severe pruritus during atopic skin inflammation, IL-31’s neuropoietic potential remains elusive.
OBJECTIVE:
We sought to analyze the IL-31-related transcriptome in sensory neurons and to investigate whether IL-31 promotes sensory nerve fiber outgrowth.
The pruritus and TH2associated cytokine IL31promotes growth of sensory nerves
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Filename : the-pruritus-and-th2associated-cytokine-il31promotes-growth-of-sensory-nerves-4.pdf (5 MB)
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Filename : the-pruritus-and-th2associated-cytokine-il31promotes-growth-of-sensory-nerves.pdf (5 MB)
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Filename : the-pruritus-and-th2associated-cytokine-il31promotes-growth-of-sensory-nerves-3.pdf (5 MB)
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