Molecules That Channel Stimulus into Pruritus

Abstract

Pruritus, a sensation that evokes a desire to scratch, is triggered by molecular cascades that result in the excitation of sensory neurons. In general, pruritogens or itch-inducing agents can induce alterations in the membrane potential, coordinated by the actions of distinctive molecules known as ion channels. These specialized molecules are membrane proteins that form distinct pores, through which specific ions can selectively flow when opened. To date, numerous ion channels have been discovered that are involved in the generation and/or transmission of pruritic signals in the vicinity of the skin. This chapter will summarize representative ion channels that play fundamental roles in pruritus.

Links

• doi:10.52305/UCLY2326

BibTeX (Download)

@inbook{nokey,
title = {Molecules That Channel Stimulus into Pruritus},
author = {Babina Sanjel and Won-Sik Shim},
editor = {Merab G. Tsagareli and Taylor Follansbee},
doi = {10.52305/UCLY2326},
isbn = {979-8-88697-757-8},
year  = {2023},
date = {2023-07-15},
urldate = {2023-07-15},
booktitle = {Histaminergic and Non-Histaminergic Itch: From Channels to Behavior},
issuetitle = {Chapter 4. Molecules That Channel Stimulus into Pruritus},
publisher = {Nova Science},
abstract = {Pruritus, a sensation that evokes a desire to scratch, is triggered by molecular cascades that result in the excitation of sensory neurons. In general, pruritogens or itch-inducing agents can induce alterations in the membrane potential, coordinated by the actions of distinctive molecules known as ion channels. These specialized molecules are membrane proteins that form distinct pores, through which specific ions can selectively flow when opened. To date, numerous ion channels have been discovered that are involved in the generation and/or transmission of pruritic signals in the vicinity of the skin. This chapter will summarize representative ion channels that play fundamental roles in pruritus.},
keywords = {Ion Channel, Itch},
pubstate = {published},
tppubtype = {inbook}
}