Apigenin ameliorates inflamed ulcerative colitis by regulating mast cell degranulation via the PAMP-MRGPRX2 feedback loop
https://doi.org/10.1016/j.phymed.2025.156564
Yihan Huang a†, Na Wang b†, Xiaolan Ji a, Shiqiong Luo a, Ling Gong a, Chenrui Zhao a, Guodong Zheng a, Rui Liu a, Tao Zhang a
aSchool of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China
bDepartment of Otolaryngology, Affiliated Hospital of North China University of Science and Technology, Tangshan 063000, China
Highlights
- MrgprB2-mediated mast cell degranulation is critical for the persistence of inflammation in colitis.
- PAMP-MrgprB2-induced pro-inflammatory positive feedback loop is critical for inflammation.
- Apigenin reduces inflammatory symptoms and improves colon damage and inflammatory cell infiltration.
- Apigenin inhibited degranulation of mast cell and carboxypeptidase A3 levels.
- Apigenin ameliorating ulcerative colitis via MRGPRX2.
Keywords
Ulcerative colitis, Mast cells, Carboxypeptidase A3, Apigenin, MRGPRX2
