Meningeal regulatory T cells inhibit nociception
In female mice
Élora Midavaine1, Beatriz C. Moraes1, Jorge Benitez1, Sian R. Rodriguez1, Joao M. Braz1, Nathan P. Kochhar1, Walter L. Eckalbar1, Lin Tian2, Ana I. Domingos3, John E. Pintar4,
Allan I. Basbaum1*†, Sakeen W. Kashem5,6
Pain prevalence is higher in women across multiple conditions, and chronic pain severity
is frequently altered during gender affirming hormonal therapy (1). Although
there is evidence that T cells contribute to sexually dimorphic pain processing, the exact
mechanisms remain unclear (2). Regulatory T cells (Treg cells) are a subset of CD4+ T cells
defined by the expression of the master transcriptional regulator FOXP3, which is encoded
by a gene found on the X chromosome. In addition to their critical function in restraining
inflammation, Treg cells are major contributors of tissue reparative and supportive functions
(3, 4). However, it is not known whether and how Treg cells directly alter neuronal activity to
modulate nociception, independently of their immunomodulatory functions (5, 6). In this
study, we examined the role of Treg cells in regulating pain sensing in mice.
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