Cortical GluK1 kainate receptors modulate scratching in adult mice
Journal of Neurochemistry | 2013 | 126 | 636-650
Kaori Yamada and Min Zhuo
Abstract
Recent investigations into the mechanisms mediating itch transmission have focused on spinal mechanisms, whereas few studies have investigated the role of the cerebral cortex in itch-related behaviors. Human imaging studies show that several cortical regions are active in correspondence with itch, including the anterior cingulate cortex (ACC). We present here evidence of cortical modulation of pruritogen-induced scratch- ing behavior. We combine pharmacological, genetic, and electrophysiological approaches to show that cortical GluK1- containing kainate (KA) receptors are involved in scratching
induced by histamine and non-histamine-dependent itching stimuli. We further show that scratching corresponds with enhanced excitatory transmission in the ACC through KA receptor modulation of inhibitory circuitry. In addition, we found that inhibiting GluK1-containing KA receptors in the ACC also reduced behavioral nociceptive responses induced by forma- lin. Our results reveal a new role of the cortex in pruritogen- induced scratching.
Keywords: cortex, glutamatergic transmission, inhibitory trans- mission, itch, kainate receptors, scratching.
J. Neurochem. (2013) 126, 636–650.
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