Activation of TRPV1 mediates thymic stromal lymphopoietin release via the Ca2+/NFAT pathway in airway epithelial cells
Xinying Jia a, Hong Zhang a, Xu Cao b,⇑, Yuxin Yin a, Bo Zhang a,⇑ a Department of Pathology, Peking University Health Science Center, 100191 Beijing, China
b Department of Neurology, Peking University Health Science Center, 100191 Beijing, China
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Abstract
The airway epithelium is exposed to a range of irritants in the environment that are known to trig- ger inflammatory response such as asthma. Transient receptor potential vanilloid 1 (TRPV1) is a Ca2+-permeable cation channel critical for detecting noxious stimuli by sensory neurons. Recently increasing evidence suggests TRPV1 is also crucially involved in the pathophysiology of asthma on airway epithelium in human. Here we report that in airway epithelial cells TRPV1 activation potently induces allergic cytokine thymic stromal lymphopoietin (TSLP) release. TSLP induction by protease-activated receptor (PAR)-2 activation is also partially mediated by TRPV1 channels.
Ó 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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