A histamine-independent itch path- way is required for allergic ocular itch
A histamine-independent itch pathway is required for allergic ocular itch
Cheng-Chiu Huang, PhDa, Yu Shin Kim, PhDb, William P. Olson, BSc, Fengxian Li, MDa, d, Changxiong Guo, BAa, Wenqin Luo, MD, PhDc, Andrew J.W. Huang, MD, MPHe, Qin Liu, PhDa, e,
From athe Department of Anesthesiology and the Center for the Study of Itch, Washing- ton University School of Medicine, St Louis, Mo; bthe Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Md; cthe Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pa; dthe Department of Anesthesiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China; and ethe Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo.
Itch is the cardinal symptom of allergic conjunctivitis and afflicts 15% to 20% of the population worldwide. Histamine produced by conjunctival mast cells has been implicated as the principal itch mediator that activates histamine receptors on primary sensory fibers to induce allergic ocular itch.1 However, antihistamines cannot completely relieve ocular itch in many cases, suggesting the involvement of a histamine-independent itch pathway. Herein, we sought to identify the histamine- independent neural pathway involved in allergic conjunctivitis and to develop new therapeutic strategies for allergic ocular itch.
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Filename : a-histamine-independent-itch-pathway-is-required-for-allergic-ocular-itch.pdf (2 MB)
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