The antimicrobial peptide hBD2 promotes itch through Toll-like receptor 4 signaling in mice.
Feng J1, Luo J1, Mack MR2, Yang P1, Zhang F3, Wang G3, Gong X3, Cai T4, Mei Z3, Kim BS2, Yin S5, Hu H6.
Abstract
The psoriasis biomarker hBD2 produces a robust scratching response in a TLR4-dependent manner in mice. TRPV1 is a downstream mediator of hBD2-induced itch. These findings suggest that hBD2 might act as an endogenous pruritogen in psoriatic itch.
KEYWORDS:
CCR2; CCR6; TLR4; TRPA1; TRPV1; chronic itch; human beta-defensin 2; psoriasis
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Filename : the-antimicrobial-peptide-hbd2-promotes-itch-through-toll-like-receptor-4-signaling-in-mice.pdf (2 MB)
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