Essential Role for TRPC5 in Amygdala Function
and Fear-Related Behavior
1-s2.0-S0092867409003766-main PIIS0092867409003766.mmc1
Antonio Riccio,1,2 Yan Li,3 Jisook Moon,3,5 Kwang-Soo Kim,3 Kiersten S. Smith,3 Uwe Rudolph,3 Svetlana Gapon,1 Gui Lan Yao,2 Evgeny Tsvetkov,3 Scott J. Rodig,4 Ashlee Van’t Veer,3 Edward G. Meloni,3 William A. Carlezon Jr.,3 Vadim Y. Bolshakov,3,* and David E. Clapham1,2,*
1Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children’s Hospital Boston, Boston, MA 02115, USA
2Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
3Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
4Department of Pathology, Brigham and Women’s Hospital, Boston, MA 02115, USA
5Present address: College of Medicine, Pochon CHA University, 606-5 Yeoksam-dong, Gangnam-gu, Seoul 135-081, Republic of Korea *Correspondence: vadimb@mclean.harvard.edu (V.Y.B.), dclapham@enders.tch.harvard.edu (D.E.C.)
DOI 10.1016/j.cell.2009.03.039
SUMMARY
The transient receptor potential channel 5 (TRPC5) is predominantly expressed in the brain where it can form heterotetrameric complexes with TRPC1 and TRPC4 channel subunits. These excitatory, nonse- lective cationic channels are regulated by G protein, phospholipase C-coupled receptors. Here, we show that TRPC5
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Filename : piis0092867409003766-mmc1.pdf (694 KB)
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