Eun Ju Kim abc, Dong Hun Lee abc, Yeon Kyung Kim abc, Min-Kyoung Kim abc, Jung Yun Kim abc, Min Jung Lee abc, Won Woo Choi abc, Hee Chul Eun abc, Jin Ho Chung abc
Summary
Background
Sensitive skin represents hyperactive sensory symptoms showing exaggerated reactions in response to internal stimulants or external irritants. Although sensitive skin is a very common condition affecting an estimated 50% of the population, its pathophysiology remains largely elusive, particularly with regard to its metabolic aspects.
Objective
The objective of our study was to investigate the pathogenesis of sensitive skin.
Methods
We recruited healthy participants with ‘sensitive’ or ‘non-sensitive’ skin based on standardized questionnaires and 10% lactic acid stinging test, and obtained skin samples for microarray analysis and subsequent experiments.
Results
Microarray transcriptome profiling revealed that genes involved in muscle contraction, carbohydrate and lipid metabolism, and ion transport and balance were significantly decreased in sensitive skin. These altered genes could account for the abnormal muscle contraction, decreased ATP amount in sensitive skin. In addition, pain-related transcripts such as TRPV1, ASIC3 and CGRP were significantly up-regulated in sensitive skin, compared with non-sensitive skin.
Conclusions
Our findings suggest that sensitive skin is closely associated with the dysfunction of muscle contraction and metabolic homeostasis.